An observational study in Progressive Supranuclear Palsy and Cognitive Impairment, sponsored by Ospedale Generale Di Zona Moriggia-Pelascini. Completed. Per ClinicalTrials.gov, last updated 2018-03-27.
Sponsored by Ospedale Generale Di Zona Moriggia-Pelascini · Observational
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
Progressive Supranuclear Palsy (PSP) is a neurodegenerative disease characterized by vertical supranuclear gaze palsy, early balance dysfunction and falls. Tau-protein aggregation, mainly in the brainstem, is the disease hallmark. Because of the similarities with Parkinson's disease (PD), the diagnosis is made approximately 4 years after the symptoms onset. Cognitive deficits are a leading feature of PSP and they actually represent one of the four functional core domains in the revised diagnostic criteria. The aim of this study is to better understand the nature of this cognitive decline, the time of its development and the relation with the other cardinal features of the disease.
56 PSP patients (PSPp) and 56 PD patients (PDp) were enrolled and matched for sex, age and disease duration.
Exclusion Criteria:
Patients suffering from Progressive Supranuclear Palsy (PSP)
Behavioral: Cognitive evaluation
Patients suffering from Parkinson's disease (PD)
Behavioral: Cognitive evaluation
An extensive battery of neuropsychological and motor tests was assessed: MMSE, FAB, MoCA, WCST, Stroop Test, TMT-A and B, Verbal fluency Test, ROCF copy and delayed recall, RAVLT, 6MWT, TUG, BBS.
MMSE
Mini-Mental State Examination
Time frame: 1 year
FAB
Frontal Assessment Battery
Time frame: 1 year
MoCA
Montreal Cognitive Assessment
Time frame: 1 year
WCST
Wisconsin Card Sorting Test
Time frame: 1 year
ST
Stroop Test
Time frame: 1 year
TMT-A and B
Trail Making Test Parts A \& B
Time frame: 1 year
VFT
Verbal fluency Test
Time frame: 1 year
ROCF copy and delayed recall
Rey-Osterrieth complex figure test copy and delayed recall
Time frame: 1 year
RAVLT
Rey Auditory Verbal Learning Test
Time frame: 1 year
6MWT
6 Minute Walk Test
Time frame: 1 year
TUG
Timed Up and Go Test
Time frame: 1 year
BBS
Berg Balance Scale
Time frame: 1 year
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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Supranuclear Palsy, Progressive→
Ospedale Generale Di Zona Moriggia-Pelascini