ClinicalTrials.gg
CompletedNCT05143320Updated Dec 3, 2021

Cognitive, Emotional and Behavioural Impairments in Patients After Sars-Cov2 Infection

An observational study in COVID-19 and Sars-CoV-2 Infection, sponsored by Ospedale Generale Di Zona Moriggia-Pelascini. Completed at 1 site in Italy. Open to participants aged 30 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-12-03.

Sponsored by Ospedale Generale Di Zona Moriggia-Pelascini · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
29
Ages
30 Years to 70 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 392 studies in COVID-19 with a site in Italy — 37 open to participants now, 46 under way, 7 of them phase 3. COVID-19 · Italy.

Enrollment
226th of 238
29 · median 251
Started
2021
with 97 others
Observational
238 of 392
24 open now
Registered
288th of 392
by date

Among the 392 studies in COVID-19 with a site in Italy, this one is the 226th largest by enrollment of the 238 observational ones that give a count, is one of 98 that started in 2021, is one of 238 observational ones, and was the 288th registered.

COVID-19

7,990 studies on the registry are indexed under COVID-19; 466 are open to participants now.

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Open to participants now

37 of the 392 studies in COVID-19 with a site in Italy are open now. Recruiting first, the newest first:

32 more — sign in →

All 37 open studies →

A study can be open while its sites in Italy have not opened yet or have stopped. Only those recruiting at a site in Italy →

Who these studies take

Of the 356 COVID-19 studies recruiting now, 207 (58%) set no upper age limit and 83 (23%) stop at 75 or younger; 91 take children under 18; 136 take healthy volunteers.

This study: 30 Years to 70 Years · all sexes · healthy volunteers too.

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02

Study summary

Recent studies suggest cognitive, emotional and behavioural impairments occur in patients after SARS-CoV-2 infection. Problems with memory, attention, information processing and executive functions are particularly prevalent in these patients, probably due to hypothesised sensitivity of the hippocampus to the virus. Cognitive impairment is also present in patients with no neurological, neuropsychological and neuropsychiatric history. Therefore, the aim of the present study is to describe neuropsychological and neuropsychiatric features in patients recovered from moderate to severe forms of Covid-19 some weeks after hospital dismission.

03

Conditions studied

  • COVID-19
  • Sars-CoV-2 Infection

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Keywords

  • Covid-19
  • Cognition
  • Teleneuropsychology
  • Memory
  • Executive Functions
04

Who can participate

Ages eligible
30 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Patients who were hospitalized in the Covid ward and recovered from the acute phase of Covid-19 with no need of ICU admission. All patients had SARS-Cov-2 infection confirmed by positive PCR from nasopharyngeal swab. Neuropsychological study was performed on average 20 days after hospital discharge to have the most recent possible cognitive profile related to the infection. We enrolled 29 healthy controls (Covid-) who did not have SARS COV 2 infections with a 1:1 match by age, education and gender.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Positive PCR from nasopharyngeal swab
  • No ICU admission

Exclusion criteria

Exclusion Criteria:

  • Diagnosis of neurologic or psychiatric disorders;
  • Previous cognitive impairment;
  • Other medical conditions negatively affecting the cognitive status.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
29 participants (actual)
Patient registry
No

Groups and cohorts

  • Covid+
  • Covid-
06

What researchers measure

Primary outcomes

  1. Cognitive and neuropsychiatirc symptoms in Covid-19 patients

    Prevalence of neuropsychological and neuropsychiatric impairment in patients after hospitalization in patients with Sars-Cov2 infection.

    Time frame: About 20 days after hospital dismission

07

Study locations

1 site
  • "Moriggia Pelascini" Hospital
    Gravedona, Como 22015, Italy
08

References and documents

Publications

  • Cian V, De Laurenzis A, Siri C, Gusmeroli A, Canesi M. Cognitive and Neuropsychiatric Features of COVID-19 Patients After Hospital Dismission: An Italian Sample. Front Psychol. 2022 May 24;13:908363. doi: 10.3389/fpsyg.2022.908363. eCollection 2022. PubMed 35686079 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Jan 2021 to primary completion in May 2021, 4 months.

Of 1,640 non-industry observational studies under COVID-19, half reached primary completion within 14 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 30. This study's 4 months is below that.

Counting every sponsor, half of 1,774 studies reached it within 13 months; a quarter within 5 and three quarters within 29.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 2, 2021
First posted
Dec 3, 2021
StartActual
Jan 8, 2021
Primary completionActual
May 21, 2021
CompletionActual
Oct 29, 2021
Last update
Dec 3, 2021
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Dec 3, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05143320
Lead sponsor
Ospedale Generale Di Zona Moriggia-Pelascini
Responsible party
Sponsor
First posted
Dec 3, 2021
Start date
Jan 8, 2021
Primary completion
May 21, 2021
Completion
Oct 29, 2021
Last update
Dec 3, 2021

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.

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