An observational study in Breast Cancer Female, sponsored by Hôpital Privé des Côtes d'Armor (HPCA). Completed at 1 site in France. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2019-01-16.
Sponsored by Hôpital Privé des Côtes d'Armor (HPCA) · Observational
Brest cancer is the most common cancer in women in France with 52.000 new cases diagnosed in 2010 including nearly 6.000 women younger than 40.
The improvement of the fertility conservation of cancer patients is one of the goals put forward by the french Cancer Plan (Objective 8.1).
The issue of fertility after a breast cancer is a frequently raised subjects by the concerned couples today. The improvement in prognosis due to therapeutic advances combined with the increasing age of the first pregnancy and in the recomposed couples bring number of young women between 35 and 40 years followed for breast cancer today to raise these questions with their oncologists.
Young women have a greater risk to develop agressive tumors requiring a mulitimodal treatment whose general and gonadic side effects can be important and permanently impact the reproductive capacity. At the time of diagnosis, almost 50% of these young patients report that they want to consider a later pregnancy but no data are available on the evolution of this wish over time although it is known that anti-cancer treatments have a serious impact on future possibilities of pregnancy(s).
The sequential chemotherapy regimen prescribed in adjuvant or neo-adjuvant situation includes intercaling agents (antracyclines) and an alkylating agent (cyclophosphamide) partially responsible for subsequent fertility disorders. In addition, a chemotherapy-induced amenorrhea (CAI) occurs in 50 to 80% of women according to the studies, the latter is sometines definitive and sequellar of treatment. However, few data describe the time of recovery of menstrual cycles in women with CAI and subsequent impact of fertility.
The aim of this study is to evaluate the impact of cancer diagnosis and treatment on the wishes of fertility before and after the management of cancer of the patients in question, on the recovery of menstrual cycles and the quality of sexual life of these patients.
The investigators hope to improve the pre-therapeutic evaluation of women wishing to implement measures to preserve fertility, to assist women wishing to consider this type of project after cytotoxic treatments and accompany women suffering from a change in self-image that has an impact on their quality of life. These results could help to sensitize the doctors to the difficulties encountered by young women and to improve and/or to strengthen the global and adapted care of these patients.
Selection criteria :
Main objective :
=> Describe the impact of diagnosis and the breast cancer care on fertility in patients younger than 40 years.
Secondary objectives :
patients aged between 18 and 40 years at the time of diagnosis of non-metastatic breast cancer and having completed their radiotherapy and/or chemotherapy treatment(s) for at least 3 months
Inclusion criteria :
Describe the impact of diagnosis and the breast cancer care on fertility in patients younger than 40 years
measurement of menstrual cycles
Time frame: through study completion, an average of 1 year
Plan to share: Undecided
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This study is completed, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
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