An interventional study of Trier social stress test and Diesel exhaust in Blood Pressure, Inflammation and Catecholamines, sponsored by University of Washington. Status unknown at 1 site in United States. Open to participants aged 22 Years to 49 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-11-05.
Sponsored by University of Washington · Not applicable, Interventional, and Other
This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypothesis is that the synergistic effect of stress and air pollution will result in higher levels of stress and inflammation (measured via biological markers) as well as poorer cardiovascular disease related outcomes compared to the independent effect of each exposure separately.
3,536 studies on the registry are indexed under Inflammation; 642 are open to participants now.
This study's planned enrollment of 22 is below the median of 50 across 2,577 interventional studies indexed under Inflammation.
Browse Inflammation studies →University of Washington is the lead sponsor of 1,433 studies on the registry; 225 are open to participants now.
Of its 158 completed or terminated interventional studies of FDA-regulated products, 136 (86%) have results posted.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Non-smokers without history of high blood pressure, asthma, diabetes, high cholesterol, post-traumatic stress disorder (PTSD) or any other chronic condition that requires ongoing care.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Subjects sit in a room for two hours breathing in filtered air which resembles levels of air pollution found in the ambient environment
Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed.
Other: Diesel exhaust
Subjects undergo a mental stress test, known as the Trier Social Stress Test (TSST), which involves a public speaking and math task.
Behavioral: Trier social stress test
Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed and are subject to a mental stress test (TSST) which involves a public speaking and math task.
Behavioral: Trier social stress test · Other: Diesel exhaust
Subjects are asked to give a 5 minute speech on a topic selected by the investigator. Then they are asked to subtract 7 from 758.
Also known as: TSST
Diesel exhaust is an air pollutant found in the environment and produced by cars, trucks and other transportation modes (e.g. trains, planes).
Change in norepinephrine
Urinary norepinephrine in ng/mg
Time frame: Change in norepinephrine from baseline (pre-exposure) to immediately after exposure
Change in epinephrine
Urinary epinephrine in ng/mg
Time frame: Change in epinephrine from baseline (pre-exposure) to immediately after exposure
Change in dopamine
Urinary dopamine in ng/mg
Time frame: Change in dopamine from baseline (pre-exposure) to immediately after exposure
Change in d-dimer
plasma d-dimer (ug/ml) is a measure of coagulation
Time frame: change in d-dimer from baseline (pre-exposure) to six hours post exposure
Change in fibrinogen
plasma fibrinogen (mg/dl) is a measure of coagulation
Time frame: change in fibrinogen from baseline (pre-exposure) to six hours post exposure
Change in interleukin-6 (IL-6)
plasma IL-6, measured in pg/ml, is a marker of inflammation
Time frame: change in IL-6 from baseline (pre-exposure) to immediately after exposure
Change in tumor necrosis factor alpha (TNF-a)
plasma TNF-a, measured in pg/ml, is a marker of inflammation
Time frame: change in TNF-a from baseline (pre-exposure) to immediately after exposure
Change in interleukin-1b (IL-1b)
plasma IL-1b, measured in pg/ml, is a marker of inflammation
Time frame: change in IL-1b from baseline (pre-exposure) to immediately after exposure
Change in blood pressure
blood pressure in mm Hg
Time frame: Change in blood pressure from baseline (pre-exposure) to 22 hours post exposure
Change in heart rate
heart rate in beats per minute
Time frame: Change in blood pressure from baseline (pre-exposure) to 60 minutes post exposure
Plan to share: Undecided — We may share some of the clinical data collected such as blood pressure, spirometry and other markers of cardiac function with researchers interested in addressing related study questions. Direct identifiers will not be stored or shared, but rather only de-identified bio-specimens and data.
No publications or documents are linked to this record.
This study is status unknown, as verified in Nov 2018. You cannot join it, but the record below documents what was studied.
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