An Early Phase 1 interventional study of Alcohol and Placebo in Alcohol Drinking, Alcohol Use Disorder and Alcohol Intoxication, sponsored by Carnegie Mellon University. Active, not recruiting at 1 site in United States. Open to participants aged 21 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-02-12.
Sponsored by Carnegie Mellon University · Early Phase 1, Interventional, and Basic science
Among 19 studies testing ethanol in Alcoholism — 7 open to participants now, 9 under way, none of them phase 3. Ethanol · Alcoholism.
Among the 19 studies testing ethanol in Alcoholism, this one is the 2nd largest by enrollment, is the only one that started in 2018, is one of 5 in phase 1, and was the 9th registered.
1,674 studies on the registry are indexed under Alcoholism; 331 are open to participants now.
This study's enrollment of 782 is above the median of 88 across 1,428 interventional studies indexed under Alcoholism.
Browse Alcoholism studies →7 of the 19 studies testing ethanol in Alcoholism are open now, in 1 country. Each count lists the studies.
Ethanol: first FDA approval 1946 (ALCOHOL 5% AND DEXTROSE 5%). What it is approved for, and how studies give it, is on its page →
Of the 239 Alcoholism studies recruiting now, 84 (35%) set no upper age limit and 133 (56%) stop at 75 or younger; 11 take children under 18; 64 take healthy volunteers.
This study: 21 Years to 29 Years · all sexes · healthy volunteers too.
The full table on the hub →19 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 1 started in 2018.
Median enrollment 144 across the 19 interventional studies. Of the 9 that completed or were terminated, 5 (56%) have results posted.
None of the 19 has an industry lead sponsor. The 10 most frequent:
Carnegie Mellon University is the lead sponsor of 46 studies on the registry; 5 are open to participants now.
Carnegie Mellon University has 1 study filed under Alcoholism — fewer than ten, so there is no comparison to draw.
5 of the studies testing ethanol in Alcoholism that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT03827460Indiana UniversitySex Differences in the Response to Abstinence From Alcohol. | 2027-02-28 |
| NCT06494891University of California, Los AngelesMotivation for IV Alcohol Self-Administration in Humans | 2027-04-30 |
| NCT04929288Jessica WeaferNeural and Hormonal Influences on Sex Differences in Risk for AUD | 2027-06-30 |
| NCT05389930Brown UniversityCannabis' Impact on Alcohol Consumption | 2027-08-31 |
| NCT05929677Jessica WeaferImpulsivity Domains and Subjective Response | 2027-09-01 |
Among the 19 studies testing ethanol in Alcoholism, from their registry updates:
This study aims to identify risk factors that prospectively predict alcohol problems in young adults.
The vast majority of alcohol use takes place in social settings, yet nearly all human experimental work has administered alcohol to individuals in isolation. This study will examine the effects of alcohol in social groups and test whether these responses predict the escalation of alcohol use and development of alcohol use disorder symptoms. Participants will also complete smartphone surveys querying subjective responses to alcohol in their daily lives.
N=400 male and female young adults will participate in a laboratory session with two other participants and will consume either a moderate dose of alcohol or placebo beverage. Subjective and objective responses to alcohol will be assessed. Participants will also complete surveys on their smartphones; these will occur during drinking episodes and at random times throughout the day. Follow-up sessions will occur at 6-months and 12-months, to collect information about drinking habits and potential alcohol-related problems.
1,674 studies on the registry are indexed under Alcoholism; 331 are open to participants now.
This study's enrollment of 782 is above the median of 88 across 1,428 interventional studies indexed under Alcoholism.
Browse Alcoholism studies →Carnegie Mellon University is the lead sponsor of 46 studies on the registry; 5 are open to participants now.
Compared within Alcoholism, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Alcohol Drinking. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
[Exclusion criteria are masked from public viewing until data collection is complete. Please contact project managers.]
Moderate dose of alcohol (target BAC .08%)
Drug: Alcohol
Other: Placebo
target BAC .08%
placebo beverage
Change from Baseline Alcohol Use at 12-months
Timeline Follow Back Method
Time frame: 12-month follow-up
Change from Baseline Alcohol Use Disorder Symptoms at 12-months
Structured Clinical Interview for DSM-5
Time frame: 12-month follow-up
Subjective Responses to Alcohol
Participants will indicate how they feel after drinking alcohol using the Brief-Biphasic Alcohol Effects Scale, which is a 6-item scale assessing alcohol's acute stimulant and sedative effects (0-10 scale, with higher scores indicating higher values).
Time frame: 1 day (laboratory session) and 21-day ambulatory assessment period
Social Bonding
Facial expressions of emotions using Paul Ekman's Facial Action Coding System (FACS). The duration of AUs associated with positive and negative affect will be coded.
Time frame: 1 day (laboratory session)
Social Bonding
Perceived Group Reinforcement Scale, which is a 12-item scale assessing self-reported bonding (1-9 scale, with higher scores indicating more bonding).
Time frame: 1 day (laboratory session)
Mood
8-item Mood Measure, which is an 8-item scale assessing mood items from each of the four quadrants of the affective circumplex (with higher scores indicating more felt emotion).
Time frame: 1 day (laboratory session)
Alcohol Use
Quantity of standard drinks consumed.
Time frame: 21-day ambulatory assessment period
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Ethanol
Carnegie Mellon University