An observational study in Coronary Heart Disease, sponsored by Chongqing Medical University. Completed at 1 site in China. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-07-17.
Sponsored by Chongqing Medical University · Observational
The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.
2,867 studies on the registry are indexed under Coronary Disease; 309 are open to participants now.
This study's enrollment of 200 is below the median of 465 across 958 observational studies indexed under Coronary Disease.
Browse Coronary Disease studies →Chongqing Medical University is the lead sponsor of 78 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with Coronary Heart Disease and Patients without Coronary Heart Disease.
All patients underwent carotid ultrasound and coronary angiograms.
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Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.
Exclusion Criteria:
Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.
Control group was defined as people with negative findings in coronary angiograms.
CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms.
DNA Methylation and Hydroxymethylation Levels
Collection of blood samples and measuring the samples by PCR and ELISA
Time frame: 1 month
This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Chongqing Medical University