An interventional study of Dual therapy and Monotherapy in Postoperative Nausea and Vomiting, sponsored by Makassed General Hospital. Completed at 1 site in Lebanon. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2019-09-27.
Sponsored by Makassed General Hospital · Not applicable, Interventional, and Other
The incidence of postoperative nausea and vomiting (PONV) after general anesthesia is up to 30% when inhalational anesthetics are used with no prophylaxis. This makes PONV one of the most common complaints following surgery under general anesthesia, together with postoperative pain.
This is a prospective, randomized, double-blind controlled clinical trial. Written informed consent will be obtained from patients. Patients will be randomly assigned using the sealed envelope technique into 2 equal groups:
Group 1: Patients will receive 10 mg metoclopramide with 4mg ondansetron before induction of general anesthesia.
Group 2: Patients will receive 10 mg metoclopramide before induction of general anesthesia.
Exclusion Criteria:
Patients will receive 10 mg metoclopramide with 4mg ondansetron before induction of general anesthesia
Other: Dual therapy · Other: General anesthesia
Patients will receive 10 mg metoclopramide before induction of general anesthesia.
Other: Monotherapy · Other: General anesthesia
combination of 10 mg metoclopramide with 4 mg ondansetron
10 mg metoclopramide
Induction of general anesthesia will be performed followed by endotracheal intubation.
postoperative nausea and vomiting
The Primary aim of this study is to compare the effect of prophylactic combination therapy (dual therapy) metoclopramide-ondansetron vs. ondansetron monotherapy for the treatment of postoperative nausea and vomiting after laparoscopic cholecystectomy. This will be assessed through a questionnaire with yes or no question where yes indicates the presence of nausea or vomiting and no indicating the absence of nausea or vomiting.
Time frame: 36 hours postoperatively
Surgeon satisfaction
Assess surgeon satisfaction with anesthesia using a questionnaire named "the Surgeon Satisfaction with Anesthesia Services Scales". The questionnaire uses a scale: 1-strongly disagree, 2- disagree, 3- agree, 4- strongly agree
Time frame: 36 hours postoperatively
Patient satisfaction
Assess patient satisfaction with anesthesia using the Iowa Satisfaction Anesthesia scale which measures patient satisfaction through a scale: strongly disagree, disagree, undecided, agree and strongly agree
Time frame: 36 hours postoperatively
This study is completed, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.
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Makassed General Hospital