An interventional study of Super Beets and Beetroot powder in Vasodilation, Blood Pressure and Active Hyperemia, sponsored by University of Iowa. Completed at 1 site in United States. Open to participants aged 60 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-01-09.
Sponsored by University of Iowa · Not applicable, Interventional, and Basic science
The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.
Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.
Exclusion Criteria:
Dietary nitrate in the form of beetroot powder (10g) mixed in water will be administered acutely
Dietary Supplement: Super Beets · Dietary Supplement: Beetroot powder
Beetroot powder devoid of nitrate (10g) will be mixed in water and administered acutely
Dietary Supplement: Super Beets · Dietary Supplement: Beetroot powder
Nitrate rich beetroot powder (10g) acutely
Nitrate devoid beetroot powder (10g) acutely
Change in Skeletal Muscle Blood Flow within the Leg via Doppler Ultrasound
Leg blood flow via Doppler ultrasound examined during dynamic knee extension exercise. Change in blood flow in response to dynamic knee exercise will be measured to examine the influence of dietary nitrate.
Time frame: Pre and 2 hours post acute ingestion of dietary nitrate and placebo with at least 5 days of separation between visits.
This study is completed, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
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University of Iowa