RecruitingNCT03458520Updated Feb 9, 2026

Pediatric PET/MR Image Registry

An observational study in Soft Tissue, Lymphoma and Osteosarcoma, sponsored by Stanford University. Recruiting at 1 site in United States. Open to participants aged Up to 40 Years. Per ClinicalTrials.gov, last updated 2026-02-09.

Sponsored by Stanford University · Observational

Study type: Observational
Model: Cohort
Time perspective: Prospective
Enrollment: 100
Ages: Up to 40 Years
Sex: All

Study summary

The purpose of this study is to compare whole body magnetic resonance (MR) imaging, whole body positron emission tomography (PET)/MR imaging, and (if available) PET/Computed Tomography (CT) imaging for the diagnosis of tumors in children and young adults. Sensitivities, specificities and diagnostic accuracies of the different imaging modalities will be compared for significant differences.

Conditions studied

Soft Tissue
Lymphoma
Osteosarcoma

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Who can participate

Ages eligible: Up to 40 Years
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Non-probability sample

Study population

Pediatric and young adult (\<40 years) male or female subjects with proven solid tumors or newly diagnosed mass strongly suspected to represent a solid tumor

Inclusion criteria

Patients with proven solid tumors or newly diagnosed mass strongly suspected to represent a solid tumor.
We might also include some patients with leukemia if there is concern for a focal lesion in any of their organs.
Participant's parents (if participant is under 18) or the participant (if participant is 18 years or older) must willingly give written informed consent prior to any image transfer to the image registry.

Exclusion criteria

Exclusion Criteria:

Patient has contraindications for MRI or PET/MR. This includes patients with cardiac pacemakers or intracranial vascular clips as well as patients with a blood glucose level > 200 mg/dl.
Lack of parental permission (if participant is younger than 18) or lack of informed consent (if participant is at least 18 years of age).
Patient has a CNS primary tumor.
Pregnant women and fetuses

Study design

Observational model: Cohort
Time perspective: Prospective
Enrollment: 100 participants (estimated)

Groups and cohorts

Image Registry
patients with proven solid tumors or newly diagnosed mass strongly suspected to represent a solid tumor will receive MR imaging, PET/MR imaging (and if available, PET/CT imaging)
Diagnostic Test: PET/MR imaging · Diagnostic Test: MR imaging · Diagnostic Test: PET/CT imaging

Interventions

Diagnostic testPET/MR imaging
undergo PET/MR imaging
Also known as: positron emission tomography
Diagnostic testMR imaging
Undergo MR imaging
Also known as: magnetic resonance imaging
Diagnostic testPET/CT imaging
Undergo PET/CT imaging
Also known as: computed tomography

What researchers measure

Primary outcomes

Number of tumors
Number of tumors detected on whole body MRI, PET/MR and (if available) PET/CT scans.
Time frame: up to 12 months

Secondary outcomes

Metabolic activity of tumors
Metabolic activity of tumors determined by Standardized Uptake Values (SUV) on PET/MR and (if available) PET/CT scans.
Time frame: up to 12 months

Study locations

1 of 1 sites recruiting

Stanford University, School of Medicine
Palo Alto, California 94304, United States
- Anne Muehe · Contact · amuehe@stanford.edu · 650-720-8601
- Heike Daldrup-Link, MD · Principal investigator
Recruiting

Registry details

Key details

Study ID: NCT03458520
Lead sponsor: Stanford University
Collaborators: National Cancer Institute (NCI)
Responsible party: Sponsor
First posted: Mar 8, 2018
Start date: Feb 1, 2018
Primary completion: Dec 31, 2026 (estimated)
Completion: Dec 31, 2026 (estimated)
Last update: Feb 9, 2026

Study contacts

Anne Muehe

Contact

amuehe@stanford.edu

650-720-8601

Heike Daldrup-Link, MD

principal investigator · Stanford University

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

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