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CompletedNCT03455907BEVARTHRALGIA2Updated May 5, 2026

Evaluation of the Frequency of Occurrence of Joint Pain With Bevacizumab in Patients With Ovarian, Colorectal or Bronchopulmonary Cancer

An observational study in Arthralgia, sponsored by University Hospital, Lille. Completed at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-05.

Sponsored by University Hospital, Lille · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
71
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 15 studies in Arthralgia with a site in France — 3 open to participants now, 3 under way, 1 of them phase 3. Arthralgia · France.

Started
2018
with 2 others
Observational
3 of 15
none open now
Registered
7th of 15
by date

Among the 15 studies in Arthralgia with a site in France, this one is one of 3 that started in 2018, is one of 3 observational ones, and was the 7th registered.

Arthralgia

277 studies on the registry are indexed under Arthralgia; 54 are open to participants now.

Browse Arthralgia studies →

Open to participants now

3 of the 15 studies in Arthralgia with a site in France are open now. Recruiting first, the newest first:

All 3 open studies →

A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →

Who these studies take

Of the 35 Arthralgia studies recruiting now, 18 (51%) set no upper age limit and 16 (46%) stop at 75 or younger; 1 takes children under 18; 9 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

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02

Study summary

Self-administered questionnaire survey to determine the presence or absence of joint pain during bevacizumab treatment for lung, ovarian, colorectal cancers.

The principal end-point is the frequency of arthralgia after 6 months of treatment with Bevacizumab.

03

Conditions studied

  • Arthralgia

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Keywords

  • Bevacizumab
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients treated with Bevacizumab for Lung, ovarian or colorectal cancers.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patient with ovarian, colorectal or lung cancer receiving bevacizumab therapy
  • Male or female (aged ≥18 years old)
  • Performance Status (PS) between 0 and 2
  • Expected life> 3 months
  • Ability to answer a self-questionnaire
  • Obtaining the non-opposition of patient participation

Exclusion criteria

Exclusion Criteria:

  • Pregnant or lactating woman
  • Rapid evolution of neoplastic pathology
  • Major cognitive disorders that do not allow filling of the self-questionnaire
  • Impossibility to submit to medical monitoring for social, psychological or geographical reasons
  • Patients under guardianship or curatorship
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
71 participants (actual)
Patient registry
No

Groups and cohorts

  • Patients

    patients with ovarian, colorectal or bronchopulmonary cancer receiving Bevacizumab

06

What researchers measure

Primary outcomes

  1. Frequency of arthralgia

    Frequency of joint manifestations of any grade according to the CTCAE (Common Terminology Criteria for Adverse Events) scale version 4.0 observed between the start of bevacizumab treatment and 6 months of treatment.

    Time frame: At 6 months

Secondary outcomes

  1. correlation between global cancer response and occurrence of arthralgia

    Time frame: baseline, at 3 months, at 6 months

  2. auto questionnaire specific to the study

    16 questions concerning the location, intensity, management of joint pain

    Time frame: Baseline at 3 months, at 6 months

07

Study locations

2 sites
  • Centre Oscar Lambret
    Lille, France
  • Hôpital Huriez. CHRU
    Lille, France
08

References and documents

Publications

  • Vauleon E, Behal H, Lebellec L, Desbarbieux R, Baldacci S, Simon N, Pannier D, Vieillard MH, Turpin A. Does bevacizumab increase joint pain in patients with cancer? Results of the prospective observational BEVARTHRALGIA study. Cancer Chemother Pharmacol. 2021 Apr;87(4):533-541. doi: 10.1007/s00280-020-04226-6. Epub 2021 Jan 12. PubMed 33438069 ↗
09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Jan 2018 to primary completion in Jan 2019, 12 months.

Of 21 observational studies under Arthralgia, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 56. This study's 12 months is below that.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 28, 2018
First posted
Mar 7, 2018
StartActual
Jan 3, 2018
Primary completionActual
Jan 31, 2019
CompletionActual
Jan 31, 2019
Last update
May 5, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on May 5, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03455907
Responsible party
Sponsor
First posted
Mar 7, 2018
Start date
Jan 3, 2018
Primary completion
Jan 31, 2019
Completion
Jan 31, 2019
Last update
May 5, 2026

Study contacts

Marie-Hélène Viellard, MD
principal investigator · University Hospital, Lille

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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