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CompletedNCT03455907BEVARTHRALGIA2Updated May 5, 2026

Evaluation of the Frequency of Occurrence of Joint Pain With Bevacizumab in Patients With Ovarian, Colorectal or Bronchopulmonary Cancer

An observational study in Arthralgia, sponsored by University Hospital, Lille. Completed at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-05.

Sponsored by University Hospital, Lille · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
71
Ages
18 Years and older
Sex
All
01

Study summary

Self-administered questionnaire survey to determine the presence or absence of joint pain during bevacizumab treatment for lung, ovarian, colorectal cancers.

The principal end-point is the frequency of arthralgia after 6 months of treatment with Bevacizumab.

02

Conditions studied

  • Arthralgia

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Keywords

  • Bevacizumab
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients treated with Bevacizumab for Lung, ovarian or colorectal cancers.

Inclusion criteria

  • Patient with ovarian, colorectal or lung cancer receiving bevacizumab therapy
  • Male or female (aged ≥18 years old)
  • Performance Status (PS) between 0 and 2
  • Expected life> 3 months
  • Ability to answer a self-questionnaire
  • Obtaining the non-opposition of patient participation

Exclusion criteria

Exclusion Criteria:

  • Pregnant or lactating woman
  • Rapid evolution of neoplastic pathology
  • Major cognitive disorders that do not allow filling of the self-questionnaire
  • Impossibility to submit to medical monitoring for social, psychological or geographical reasons
  • Patients under guardianship or curatorship
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
71 participants (actual)
Patient registry
No

Groups and cohorts

  • Patients

    patients with ovarian, colorectal or bronchopulmonary cancer receiving Bevacizumab

05

What researchers measure

Primary outcomes

  1. Frequency of arthralgia

    Frequency of joint manifestations of any grade according to the CTCAE (Common Terminology Criteria for Adverse Events) scale version 4.0 observed between the start of bevacizumab treatment and 6 months of treatment.

    Time frame: At 6 months

Secondary outcomes

  1. correlation between global cancer response and occurrence of arthralgia

    Time frame: baseline, at 3 months, at 6 months

  2. auto questionnaire specific to the study

    16 questions concerning the location, intensity, management of joint pain

    Time frame: Baseline at 3 months, at 6 months

06

Study locations

2 sites
  • Centre Oscar Lambret
    Lille, France
  • Hôpital Huriez. CHRU
    Lille, France
07

References and documents

Publications

  • Vauleon E, Behal H, Lebellec L, Desbarbieux R, Baldacci S, Simon N, Pannier D, Vieillard MH, Turpin A. Does bevacizumab increase joint pain in patients with cancer? Results of the prospective observational BEVARTHRALGIA study. Cancer Chemother Pharmacol. 2021 Apr;87(4):533-541. doi: 10.1007/s00280-020-04226-6. Epub 2021 Jan 12. PubMed 33438069 ↗
08

Registry details

Key details

Study ID
NCT03455907
Lead sponsor
University Hospital, Lille
Responsible party
Sponsor
First posted
Mar 7, 2018
Start date
Jan 3, 2018
Primary completion
Jan 31, 2019
Completion
Jan 31, 2019
Last update
May 5, 2026

Study contacts

Marie-Hélène Viellard, MD
principal investigator · University Hospital, Lille

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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