An interventional study of PEG- 17 gm sachet and Lactulose : 20-30gm in Cirrhosis, sponsored by Institute of Liver and Biliary Sciences, India. Status unknown at 1 site in India. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2018-02-28.
Sponsored by Institute of Liver and Biliary Sciences, India · Not applicable, Interventional, and Treatment
All patients presenting to the emergency department of Institute of Liver and Biliary Sciences with known cirrhosis and hepatic encephalopathy with grade II will be included in the study. The patient will be randomized into one of the two arms of lactulose or polyethylene glycol. The patient on the lactulose arm will be administered 20 to 30 g of lactulose orally or by nasogastric tube (3 or more doses within 24 hours ) or if oral intake was not possible or inadequate. The Dose will be repeated to ensure 3-4 loose motions per day. The Polyethylene Glycol group will get 17 gm of PEG (Polyethylene Glycol) administered orally or via nasogastric tube. PEG (Polyethylene Glycol)will be administered in 3-4 doses in 24 hours to ensure 3-4 loose stools per day.
1,270 studies on the registry are indexed under Fibrosis; 276 are open to participants now.
This study's planned enrollment of 110 is above the median of 63 across 840 interventional studies indexed under Fibrosis.
Browse Fibrosis studies →Institute of Liver and Biliary Sciences, India is the lead sponsor of 302 studies on the registry; 87 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Blood tests of how long blood takes to clot. The INR is the prothrombin time (PT) put on a common scale; about 1 is usual for someone not taking a blood thinner.
Criteria often make an exception for people on a blood thinner such as warfarin, whose INR is raised on purpose.
INR, PT and aPTT (clotting tests)
Blood tests of how long blood takes to clot. The INR is the prothrombin time (PT) put on a common scale; about 1 is usual for someone not taking a blood thinner.
Criteria often make an exception for people on a blood thinner such as warfarin, whose INR is raised on purpose.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Lactulose : 20-30gm 2-3 doses per day
Drug: Lactulose : 20-30gm
PEG (Polyethlene Glycol)- 17 gm sachet 3-4 times per day
Drug: PEG- 17 gm sachet
PEG- 17 gm sachet 3-4 times per day
Lactulose : 20-30gm
Complete reversal of hepatic encephalopathy in both groups.
Complete reversal is defined as Grade 0 Encephalopathy
Time frame: 3 days
Improvement in hepatic encephalopathy by two grades in both groups
Time frame: 3 days
Length of Intensive Care Unit stay in both groups
Time frame: 28 days
Adverse events in both groups
Time frame: 3 days
Presence of encephalopathy changes in Electroencephalography in both groups
Time frame: 3 days
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.
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