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CompletedNCT03447002Updated Nov 14, 2019

Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

An observational study in Premature Ventricular Contraction, sponsored by TC Erciyes University. Completed at 1 site in Turkey. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2019-11-14.

Sponsored by TC Erciyes University · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
100
Ages
18 Years to 90 Years
Sex
All
01

Study summary

Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Read the detailed description

Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

02

Conditions studied

  • Premature Ventricular Contraction

Keywords

  • premature
  • pvc
03

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

patients with % 5 or higher frequents premature ventricular complex in 24 hours rhythm recording will be taken our study.

Inclusion criteria

  • PVC's rate is more than % 5 in 24 hours rhythm recording

Exclusion criteria

Exclusion Criteria:

  • ischemic heart disease
  • hyperthyroidism
  • patients with low ejection fraction
04

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
100 participants (actual)
Patient registry
No

Interventions

  • Diagnostic test24 hours urine levels metanephrine and normetanephrine

    24 hours rhythm recording and 24 hours urine measurement

    Also known as: rhythm recording

05

What researchers measure

Primary outcomes

  1. metanephrine and normetanephrine levels

    metanephrine and normetanephrine levels asociated premature ventricular complex frequents

    Time frame: about 10 months

06

Study locations

1 site
  • Erciyes university Yilmaz- mehmet öztaşkın heart hospital
    Kayseri, Turkey
07

References and documents

Publications

  • Im SI, Park KM, Park SJ, Kim JS, On YK. New electrocardiographic criteria for predicting successful ablation of premature ventricular contractions from the right coronary cusp. Int J Cardiol. 2016 Dec 1;224:199-205. doi: 10.1016/j.ijcard.2016.09.029. Epub 2016 Sep 16. PubMed 27657474 ↗
  • Bradfield JS, Homsi M, Shivkumar K, Miller JM. Coupling interval variability differentiates ventricular ectopic complexes arising in the aortic sinus of valsalva and great cardiac vein from other sources: mechanistic and arrhythmic risk implications. J Am Coll Cardiol. 2014 May 27;63(20):2151-2158. doi: 10.1016/j.jacc.2014.02.551. Epub 2014 Mar 19. PubMed 24657687 ↗
08

Registry details

Key details

Study ID
NCT03447002
Lead sponsor
TC Erciyes University
Responsible party
Burak Cesur (burak cesur, TC Erciyes University) — Principal investigator
First posted
Feb 27, 2018
Start date
Feb 15, 2018
Primary completion
Sep 30, 2019
Completion
Sep 30, 2019
Last update
Nov 14, 2019

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Nov 2019. You cannot join it, but the record below documents what was studied.

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