An interventional study of JUUL electronic cigarette and IQOS electronic cigarette in Electronic Cigarettes, sponsored by Virginia Commonwealth University. Completed at 1 site in United States. Open to participants aged 21 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-08-03.
Sponsored by Virginia Commonwealth University · Not applicable, Interventional, and Other
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Among 14 studies in Vaping by Virginia Commonwealth University — none open to participants now, none under way, none of them phase 3. Vaping · Virginia Commonwealth University.
Among the 14 studies in Vaping by Virginia Commonwealth University, this one is the 8th largest by enrollment of the 13 interventional ones that give a count, is the only one that started in 2018, is one of 12 with no phase, and was the 1st registered.
402 studies on the registry are indexed under Vaping; 96 are open to participants now.
Browse Vaping studies →None of the 14 studies in Vaping by Virginia Commonwealth University is open now. The open studies under Vaping, anywhere →
Of the 64 Vaping studies recruiting now, 32 (50%) set no upper age limit and 31 (48%) stop at 75 or younger; 13 take children under 18; 40 take healthy volunteers.
This study: 21 Years to 55 Years · all sexes · healthy volunteers too.
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14 studies; the count open now beside each. This study's row is marked.
First in 2018; this study’s year is marked. 1 started in 2018.
This study's enrollment of 22 is below the median of 80 across 323 interventional studies indexed under Vaping.
Median enrollment 32 across the 13 interventional studies, 41 across the 1 observational. Of the 14 that completed or were terminated, 10 (71%) have results posted.
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Virginia Commonwealth University is the lead sponsor of 648 studies on the registry; 80 are open to participants now.
Of its 90 completed or terminated interventional studies of FDA-regulated products, 64 (71%) have results posted.
None of the studies under way reaches primary completion within a year.
Among the 14 studies in Vaping by Virginia Commonwealth University, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The purpose of this study is to determine differences in nicotine delivery, user behavior, subjective effects, and physiological effects, when cigarette smokers use an two new electronic cigarette devices (JUUL and IQOS) relative to their using their own brand of cigarettes.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Some study details about the eligibility criteria are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will come in for three session. During one session, participants will first complete a 10-puff product use bout with JUUL, and then a 90-minute ad lib product use bout with JUUL (the session will be approximately 3 hours). During one session, participants will first complete a 10-puff product use bout with IQOS, and then a 90-minute ad lib product use bout with IQOS (the session will be approximately 3 hours). During one session, participants will first complete a 10-puff product use bout with their own brand cigarettes, and then a 90-minute ad lib product use bout with their own brand cigarette (the session will be approximately 3 hours). The order of the sessions will be determined randomly and data about session will not be recorded or used in the analysis.
Other: JUUL electronic cigarette · Other: IQOS electronic cigarette · Other: Own Brand cigarette
Effects of JUUL electronic cigarette use.
Effects of IQOS electronic cigarette use.
Effects of own brand cigarette use.
Change in Plasma Nicotine
Change in plasma nicotine level
Time frame: Blood will be taken 4 times in each session: at baseline, 5 min after the start of a 10-puff product use, and then before and after an approximately 1-hour ad lib use period.
Carbon Monoxide Levels
Carbon monoxide levels (in parts per mission)
Time frame: Carbon monoxide levels will be assessed before and after product use in each approximately 4-hr session: at baseline, 5 min after the end of a 10-puff product use, and then before and after an approximately 1-hour ad lib use period.
Tiffany-Drobes Questionnaire of Smoking Urges - Factor 1
This scale is used to assess the extent to which product use reduces the intention to smoke a cigarette, and consists of 5 items that are scored 0 - 7, in which participants clicked seven discrete ratings from 'not at all' to 'extremely'. The items are summed and scores range from 0 to 30 with higher scores indicating higher craving for a cigarette.
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Tiffany-Drobes Questionnaire of Smoking Urges - Factor 2
This scale is used to assess the extent to which product use reduces the intention to smoke a cigarette, and consists of 4 items that are scored 0 - 7, in which participants clicked seven discrete ratings from 'not at all' to 'extremely'. The items are summed and scores range from 0 to 24 with higher scores indicating higher craving for a cigarette.
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Anxious
This scale is used to assess the extent to which product use affects on anxiety and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Craving
This scale is used to assess the extent to which product use affects on craving a cigarette and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Depression
This scale is used to assess the extent to which product use affects on depression and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Difficulty Concentrating
This scale is used to assess the extent to which product use affects having difficulty concentrating and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Drowsy
This scale is used to assess the extent to which product use affects feeling drowsy and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Hunger
This scale is used to assess the extent to which product use affects reducing hunger and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Impatient
This scale is used to assess the extent to which product use affects feeling impatient and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Irritable
This scale is used to assess the extent to which product use affects feeling irritable and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Restless
This scale is used to assess the extent to which product use affects feeling restless and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Desire for Sweets
This scale is used to assess the extent to which product use affects having desire for sweets and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Hughes-Hatsukami Questionnaire - Urge to Smoke
This scale is used to assess the extent to which product use affects having the urge to smoke and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
Time frame: Questionnaire will be administered 4 times in each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Direct Effects of Nicotine Questionnaire - Awake
One question is used to assess how much product use makes participants feel awake, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Direct Effects of Nicotine Questionnaire - Calm
One question is used to assess how much product use makes participants feel calm, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Direct Effects of Nicotine Questionnaire - Concentrate
One question is used to assess how much product use helps participants concentrate, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Direct Effects of Nicotine Questionnaire - Dizzy
One question is used to assess how much product use makes participants feel dizzy, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Direct Effects of Nicotine Questionnaire - Reduce Hunger
One question is used to assess how much product use reduces feeling of hunger, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Direct Effects of Nicotine Questionnaire - Sick
One question is used to assess how much product use makes participants feel sick, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 4 times in each each approximately 4-hr session: before any product use, 10 minutes after the start of a 10-puff use bout, and then before and after an approximately 1-hour ad lib use period.
Direct Effects of Product Use Questionnaire - Pleasant
A single question is used to assess if product use felt pleasant, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 2 times in each each approximately 4-hr session: 10 minutes after the start of a 10-puff use bout, and then after an approxiamtely 1-hour ad lib use period.
Direct Effects of Product Use Questionnaire - Taste Good
A single question is used to assess if product use tasted good, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 2 times in each each approximately 4-hr session: 10 minutes after the start of a 10-puff use bout, and then after an approxiamtely 1-hour ad lib use period.
Direct Effects of Product Use Questionnaire - Satisfying
A single question is used to assess if product use felt satisfying, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 2 times in each each approximately 4-hr session: 10 minutes after the start of a 10-puff use bout, and then after an approxiamtely 1-hour ad lib use period.
Direct Effects of Product Use Questionnaire - Smoke Right Now
A single question is used to assess if product use made them want to use the product again right now, and is scored 0 (not at all) to 100 (extremely).
Time frame: Questionnaire will be administered 2 times in each each approximately 4-hr session: 10 minutes after the start of a 10-puff use bout, and then after an approxiamtely 1-hour ad lib use period.
Heart Rate
Change in heart rate, measured in beats per minute
Time frame: Heat rate will be measured from baseline continuously throughout each each approximately 4-hr session
Blood Pressure
Change in blood pressure, measured in mm/hg
Time frame: Blood pressure will be measured from baseline continuously throughout each approximately 4-hr session
| Milestone | Electronic Cigarette vs Own Brand Use |
|---|---|
| Started | 22 |
| Completed | 18 |
| Not completed | 4 |
Change in plasma nicotine level
| ng/ml | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use | Own Brand Cigarette Use |
|---|---|---|---|
| Post puff bout | 7.62 ± 4.86 | 10.65 ± 6.20 | 18.31 ± 11.39 |
| Post ad lib | 7.19 ± 8.32 | 5.97 ± 7.70 | 12.23 ± 9.26 |
Carbon monoxide levels (in parts per mission)
| Parts per mission | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 5.2 ± 2.4 | 5.5 ± 2.4 | 5.3 ± 2.0 |
| Post puff bout | 8.7 ± 2.5 | 5.1 ± 2.3 | 4.9 ± 1.8 |
| Pre ad lib | 8.8 ± 2.8 | 5.3 ± 2.4 | 4.6 ± 1.8 |
| Post ad lib | 16.6 ± 7.0 | 4.7 ± 1.9 | 4.3 ± 1.4 |
This scale is used to assess the extent to which product use reduces the intention to smoke a cigarette, and consists of 5 items that are scored 0 - 7, in which participants clicked seven discrete ratings from 'not at all' to 'extremely'. The items are summed and scores range from 0 to 30 with higher scores indicating higher craving for a cigarette.
| score on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 24.8 ± 8.2 | 24.7 ± 7.5 | 25.1 ± 8.2 |
| Post puff bout | 13.2 ± 10.7 | 20.1 ± 9.3 | 16.0 ± 9.3 |
| Pre ad lib | 21.2 ± 8.9 | 21.7 ± 9.3 | 20.4 ± 8.5 |
| Post ad lib | 11.5 ± 10.2 | 17.8 ± 10.6 | 14.4 ± 9.7 |
This scale is used to assess the extent to which product use reduces the intention to smoke a cigarette, and consists of 4 items that are scored 0 - 7, in which participants clicked seven discrete ratings from 'not at all' to 'extremely'. The items are summed and scores range from 0 to 24 with higher scores indicating higher craving for a cigarette.
| score on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 11.7 ± 8.3 | 10.3 ± 8.3 | 12.5 ± 8.4 |
| Post puff bout | 6.9 ± 7.4 | 8.1 ± 7.8 | 6.6 ± 7.8 |
| Pre ad lib | 9.7 ± 7.4 | 9.5 ± 7.5 | 9.1 ± 8.6 |
| Post ad lib | 5.5 ± 7.6 | 6.5 ± 7.2 | 6.6 ± 8.9 |
This scale is used to assess the extent to which product use affects on anxiety and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| score on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 46.3 ± 32.5 | 42.8 ± 31.9 | 44.5 ± 34.9 |
| Post puff bout | 24.8 ± 30.6 | 24.4 ± 31.8 | 28.4 ± 33.9 |
| Pre ad lib | 22.1 ± 22.8 | 20.8 ± 30.1 | 17.2 ± 27.2 |
| Post ad lib | 19.4 ± 27.5 | 20.4 ± 27 | 28.4 ± 32.6 |
This scale is used to assess the extent to which product use affects on craving a cigarette and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 75.2 ± 30.7 | 70.5 ± 30.9 | 73.5 ± 33.5 |
| Post puff bout | 34.9 ± 35 | 49.3 ± 36.0 | 42.9 ± 31.8 |
| Pre ad lib | 55.2 ± 30.5 | 54.0 ± 38 | 53.8 ± 29.9 |
| Post ad lib | 25.5 ± 29.2 | 53.9 ± 34.9 | 36.2 ± 32.1 |
This scale is used to assess the extent to which product use affects on depression and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 21.4 ± 28.3 | 15.1 ± 20.9 | 20.5 ± 26.1 |
| Post puff bout | 9.8 ± 16.8 | 8.8 ± 16.6 | 15.1 ± 22.6 |
| Pre ad lib | 11.5 ± 21.5 | 8.1 ± 17.0 | 10.6 ± 20.1 |
| Post ad lib | 8.8 ± 13.6 | 8.2 ± 16.3 | 11.5 ± 21.7 |
This scale is used to assess the extent to which product use affects having difficulty concentrating and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 28.2 ± 26.4 | 37.6 ± 30.1 | 30.0 ± 31.9 |
| Post puff bout | 18.5 ± 20.4 | 17.3 ± 19.9 | 24.4 ± 29.9 |
| Pre ad lib | 18.1 ± 20.8 | 15.5 ± 22.5 | 16.8 ± 20.6 |
| Post ad lib | 10.4 ± 18.1 | 17.8 ± 25.8 | 18.9 ± 27.0 |
This scale is used to assess the extent to which product use affects feeling drowsy and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 35.2 ± 25 | 33.8 ± 28.2 | 31.9 ± 33.9 |
| Post puff bout | 28.7 ± 26.1 | 21.4 ± 24.6 | 29.4 ± 26.5 |
| Pre ad lib | 24.9 ± 24.3 | 25.9 ± 31.1 | 23.4 ± 24.6 |
| Post ad lib | 23.4 ± 26.9 | 25.3 ± 27.0 | 27.4 ± 29.8 |
This scale is used to assess the extent to which product use affects reducing hunger and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 39.9 ± 22.7 | 43.2 ± 29.8 | 43.0 ± 35.5 |
| Post puff bout | 31.9 ± 24.4 | 35.6 ± 33.3 | 30.2 ± 25.5 |
| Pre ad lib | 34.8 ± 25.9 | 39.5 ± 35.9 | 37.7 ± 29.0 |
| Post ad lib | 39.8 ± 30.7 | 58.4 ± 29.0 | 53.2 ± 31.9 |
This scale is used to assess the extent to which product use affects feeling impatient and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 42.1 ± 28.3 | 41.0 ± 30.6 | 51.4 ± 31.0 |
| Post puff bout | 23.9 ± 27.3 | 25.9 ± 31.0 | 25.1 ± 30.9 |
| Pre ad lib | 26.9 ± 29.3 | 31.4 ± 28.9 | 29.7 ± 30.3 |
| Post ad lib | 25.5 ± 28.2 | 31.8 ± 30.5 | 27.2 ± 27.0 |
This scale is used to assess the extent to which product use affects feeling irritable and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 37.4 ± 31.0 | 34.5 ± 31.1 | 38.7 ± 33.3 |
| Post puff bout | 14.9 ± 17.2 | 18.4 ± 22.1 | 19.8 ± 26.3 |
| Pre ad lib | 14.1 ± 16.0 | 15.4 ± 22.3 | 16.8 ± 21.0 |
| Post ad lib | 14.6 ± 22.0 | 15.1 ± 26.4 | 16.8 ± 24.1 |
This scale is used to assess the extent to which product use affects feeling restless and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 40.8 ± 29.4 | 30.2 ± 25.5 | 28.9 ± 31.8 |
| Post puff bout | 19.7 ± 24.8 | 26.9 ± 25.9 | 19.7 ± 24.6 |
| Pre ad lib | 27.7 ± 27.2 | 17.9 ± 25.7 | 33.4 ± 31.4 |
| Post ad lib | 21.5 ± 28.1 | 24.7 ± 27.6 | 27.1 ± 28.4 |
This scale is used to assess the extent to which product use affects having desire for sweets and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 24.2 ± 30.7 | 27.4 ± 33.3 | 24.8 ± 28.3 |
| Post puff bout | 16.8 ± 21.4 | 20.3 ± 27.2 | 16.4 ± 25.7 |
| Pre ad lib | 18.8 ± 25.8 | 20.7 ± 28.1 | 23.8 ± 27.9 |
| Post ad lib | 17.9 ± 21.3 | 17.4 ± 24.0 | 20.5 ± 27.0 |
This scale is used to assess the extent to which product use affects having the urge to smoke and consists of 1 item scored 0 - 100 with 0 being not at all and 100 being extremely.
| points on a scale | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Pre puff bout | 76.5 ± 25.2 | 67.2 ± 29.9 | 74.7 ± 31.5 |
| Post puff bout | 39.2 ± 34.8 | 48.8 ± 31.9 | 46.2 ± 29.5 |
| Pre ad lib | 54.4 ± 27.6 | 46.9 ± 33.3 | 56.9 ± 27.8 |
| Post ad lib | 24.9 ± 25.7 | 50.0 ± 31.1 | 38 ± 31.8 |
One question is used to assess how much product use makes participants feel awake, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 40.9 ± 31.7 | 33.8 ± 29.9 | 36.5 ± 30.6 |
| Post ad lib | 45.1 ± 31.3 | 28.1 ± 29.6 | 34.5 ± 27.4 |
One question is used to assess how much product use makes participants feel calm, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 60.9 ± 36 | 47.9 ± 31.9 | 54.4 ± 31.5 |
| Post ad lib | 60.7 ± 35.3 | 46.6 ± 29.7 | 43.2 ± 34.5 |
One question is used to assess how much product use helps participants concentrate, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 34.8 ± 30.8 | 24.5 ± 26.3 | 38.5 ± 33.7 |
| Post ad lib | 42.0 ± 34.3 | 27.5 ± 26.3 | 27.8 ± 27.1 |
One question is used to assess how much product use makes participants feel dizzy, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 40.7 ± 33.4 | 33.7 ± 33.5 | 36.4 ± 33.7 |
| Post ad lib | 30.1 ± 36.2 | 19.4 ± 27.2 | 26.9 ± 25.8 |
One question is used to assess how much product use reduces feeling of hunger, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 41.9 ± 29.9 | 35.2 ± 27.4 | 29.2 ± 28.8 |
| Post ad lib | 33.0 ± 27.7 | 37.1 ± 31.0 | 34.3 ± 26.1 |
One question is used to assess how much product use makes participants feel sick, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 4.1 ± 7.5 | 8.1 ± 14.2 | 9.5 ± 19.0 |
| Post ad lib | 2.6 ± 5.2 | 7.8 ± 14.4 | 10.5 ± 16.8 |
A single question is used to assess if product use felt pleasant, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 81.4 ± 29.8 | 50.4 ± 31.6 | 58.8 ± 36.0 |
| Post ad lib | 81.9 ± 24.9 | 50.6 ± 31.2 | 58.9 ± 34.4 |
A single question is used to assess if product use tasted good, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 77.7 ± 29.5 | 50.5 ± 32.6 | 54.6 ± 36.4 |
| Post ad lib | 74.0 ± 32.1 | 51.2 ± 30.7 | 49.8 ± 35.7 |
A single question is used to assess if product use felt satisfying, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 84.3 ± 24.4 | 47.0 ± 33.2 | 58.8 ± 30.9 |
| Post ad lib | 83.7 ± 24.5 | 46.5 ± 31.5 | 58.8 ± 33.3 |
A single question is used to assess if product use made them want to use the product again right now, and is scored 0 (not at all) to 100 (extremely).
| score on a question | Own Brand Cigarette Use | JUUL Electronic Cigarette Use | IQOS Electronic Cigarette Use |
|---|---|---|---|
| Post puff bout | 62.8 ± 37.7 | 45.4 ± 32.7 | 47.2 ± 39.1 |
| Post ad lib | 44.1 ± 37.7 | 35.5 ± 29.1 | 37.5 ± 33.5 |
Change in heart rate, measured in beats per minute
Results for this outcome have not been posted.
Change in blood pressure, measured in mm/hg
Results for this outcome have not been posted.
Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| JUUL Electronic Cigarette Use | — | — | — |
| IQOS Electronic Cigarette Use | — | — | — |
| Own Brand Cigarette Use | — | — | — |
| Age, Continuous(years) | Electronic Cigarette vs Own Brand Use |
|---|---|
| Mean | 36.8 ± 9.3 |
| Sex: Female, Male(Participants) | Electronic Cigarette vs Own Brand Use |
|---|---|
| Female | 5 |
| Male | 13 |
| Ethnicity (NIH/OMB)(Participants) | Electronic Cigarette vs Own Brand Use |
|---|---|
| Hispanic or Latino | 1 |
| Not Hispanic or Latino | 15 |
| Unknown or Not Reported | 2 |
| Race (NIH/OMB)(Participants) | Electronic Cigarette vs Own Brand Use |
|---|---|
| American Indian or Alaska Native | 0 |
| Asian | 0 |
| Native Hawaiian or Other Pacific Islander | 0 |
| Black or African American | 7 |
| White | 8 |
| More than one race | 2 |
| Unknown or Not Reported | 1 |
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Ran from Mar 2018 to primary completion in Aug 2019, 17 months.
Results were first posted in Aug 2020, 11 months after primary completion.
Of 184 non-industry interventional studies with no phase under Vaping, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 35. This study's 17 months is below that.
Counting every sponsor, half of 208 studies reached it within 18 months; a quarter within 6 and three quarters within 31.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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