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CompletedNCT03435120CAVIDIOMUpdated Mar 2, 2020

Quality of Life Study Breakthrough Cancer Pain Treated in Medical Oncology Services (CAVIDIOM)

An observational study in Breakthrough Pain, sponsored by Angelini Farmacéutica. Completed at 14 sites in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-03-02.

Sponsored by Angelini Farmacéutica · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
118
Ages
18 Years and older
Sex
All
01

Study summary

In cancer patients, pain is one of the most common symptoms. The range of reported prevalence of pain varies from 33% to 64% including different stages of cancer, during or after anticancer treatment. Moreover, despite the optimal management of basal chronic pain, 66% of these patients have reported breakthrough pain which has a severe impact on quality of life. There is insufficient clinical information on the quality of life of cancer patients with breakthrough pain treated in medical oncology services according to routine clinical practice. For this reason we consider it is appropriate to prospectively evaluate the quality of life of cancer patients with cancer breakthrough pain in medical oncology services as well as other factors that can affect quality of life. This post-authorization observational study will assess the quality of life of cancer patients with breakthrough cancer pain treated in medical oncology services in Spanish hospitals.

02

Conditions studied

  • Breakthrough Pain

Keywords

  • Breakthrough Cancer Pain
  • Quality of life
  • Medical Oncology
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with breakthrough cancer pain treated in Medical Oncology services

Inclusion criteria

  • Patients > 18 years
  • Patients with histologically confirmed neoplasia
  • Patients attended in medical oncology consultations
  • Life expectancy > 3 months
  • Patients with baseline controlled cancer pain with opioids who are diagnosed of breakthrough cancer pain by Davies algorithm
  • Written informed consent

Exclusion criteria

Exclusion Criteria:

  • Untreated patients with opioids for baseline pain
  • Patients who are not opioid tolerant
  • Serious psychiatric disorder or any disease or condition that prevents the collection of data
  • Patients with evidence of opioid addiction or history of drug or alcohol abuse
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
118 participants (actual)
Patient registry
No

Groups and cohorts

  • Breakthrough Cancer Pain

    No intervention (Non Interventional Study)

    Other: No intervention

Interventions

  • OtherNo intervention

    No intervention

05

What researchers measure

Primary outcomes

  1. Changes in quality of life of the patients

    Changes according to EQ-5D-5L questionnaire

    Time frame: Up to 4 weeks

Secondary outcomes

  1. Characteristics of patients

    Kind of tumor.

    Time frame: At baseline

  2. Characteristics of patients

    Demographic data

    Time frame: At baseline

  3. Characteristics of patients

    ECOG

    Time frame: At baseline

  4. Management of cancer breakthrough pain.

    Cancer breakthrough pain characteristics (time until maximum intensity)

    Time frame: Up to 4 weeks

  5. Management of cancer breakthrough pain.

    Cancer breakthrough pain evolution (duration and management)

    Time frame: Up to 4 weeks

  6. Anxiety and depression status and the possible relationship between these factors and quality of life.

    Goldberg Anxiety and Depression Scale.

    Time frame: Up to 4 weeks

  7. Sleep quality and the possible relationship between this factor and quality of life.

    MOS sleep questionnaire

    Time frame: Up to 4 weeks

  8. Evaluate caregivers effort

    Results according to caregivers effort Index

    Time frame: Up to 4 weeks

  9. Perceived assistance quality by patients

    Results according to Sociofamily evaluation scale of "Gijon"

    Time frame: Up to 4 weeks

  10. Improvement impression perceived by patients

    Results according to assessment of perceived quality (questionnaire of the Ministry of Health and Consumer Affairs)

    Time frame: Up to 4 weeks

  11. Improvement impression perceived by patients

    Results according to Satisfaction questionnaire PGI-I

    Time frame: Up to 4 weeks

  12. Improvement impression perceived by patients

    Results according to Satisfaction questionnaire CGI-I

    Time frame: Up to 4 weeks

06

Study locations

14 sites
  • Complexo Hospitalario Universitario de Santiago
    Santiago De Compostela, A Coruña 15706, Spain
  • Hospital Universitario Central de Asturias
    Oviedo, Asturias 33011, Spain
  • Hospital Principe de Asturias
    Alcalá De Henares, Madrid, Spain
  • Hospital Universitari Son Espases
    Palma De Mallorca, Palma, Spain
  • Hospital Universitari de San Joan de Reus
    Reus, Tarragona 43204, Spain
  • Hospital Verge de la Cinta
    Tortosa, Tarragona 43500, Spain
  • Hospital San Pedro de Alcántara
    Cáceres, 10002, Spain
  • Hospital Arnau de Vilanova
    Lleida, 25198, Spain
  • Hospital Universitario La Paz
    Madrid, 28023, Spain
  • Hospital Ramón y Cajal
    Madrid, 28034, Spain
  • Hospital Clínico San Carlos
    Madrid, 28040, Spain
  • Hospital Universitario de Salamanca
    Salamanca, 37007, Spain
  • Hospital Alvaro Cunqueiro
    Vigo, Spain
  • Hospital Universitario Miguel Servet
    Zaragoza, 50009, Spain
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03435120
Lead sponsor
Angelini Farmacéutica
Collaborators
Apices Soluciones S.L.
Responsible party
Sponsor
First posted
Feb 15, 2018
Start date
Dec 21, 2017
Primary completion
Jan 24, 2020
Completion
Feb 14, 2020
Last update
Mar 2, 2020

Study contacts

Carlos Camps Herrero
principal investigator · Hospital General Universitario de Valencia

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.

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