CClinicalTrials.gg
CompletedNCT03425695Updated Feb 8, 2018

Free Gingival Graft Adjunct With Low Level Laser Therapy

An interventional study of CheseeTM Diode Laser and Clinical examination in Wounds and Injuries, Transplants and Gingival Recession, Localized, sponsored by Abant Izzet Baysal University. Completed. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-02-08.

Sponsored by Abant Izzet Baysal University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The present placebo-controlled parallel design clinical study was planned to determine the effect of low level laser therapy on clinical periodontal conditions and dimensions of free gingival graft as well as postoperative pain levels in the surgical area.

Read the detailed description

Background: Shrinkage of the free gingival graft (FGG) and patient's discomfort during healing period are important concerns. Therefore, this study aimed to evaluate the effect of low level laser therapy (LLLT) in terms of enhancing wound healing, reducing graft shrinkage and postoperative pain.

Methods: Thirty patients were randomly assigned to receive either FGG+ LLLT (test, n = 15) or FGG + placebo LLLT (control, n = 15). In the test group, a diode laser (aluminum-gallium-arsenide, 810 nm, 0.1 W, continuous mode, time of irradiation:60 s, energy density: 6 J/cm2, spot size:0.5 cm) was applied immediately after the FGG surgery and 1,3,7, and 14 days later. The control group received the same sequence of irradiation with the laser-off. Comparison of the graft surface areas between groups at 1st, 3rd and 6th months were made with an image-analyzing software. Complete wound epithelization, visual analogue scale (VAS) pain score of recipient site and the number of analgesic used were evaluated after the surgery.

02

Conditions studied

  • Wounds and Injuries
  • Transplants
  • Gingival Recession, Localized
  • Low-Level Light Therapy

Keywords

  • Free gingival graft, Low level laser therapy, Shrinkage
03

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Patients >18 years old
  • Patients presenting Class I or II Miller gingival recession on vital incisors in the mandibular anterior region with no caries or restoration
  • The included teeth had also keratinized gingiva \<2 mm; PI and GI\<1.
  • The patients had to be systemically healthy and non-smokers.

Exclusion criteria

Exclusion Criteria:

  • Patients presenting active periodontal disease and probing depth >3 mm; taking medications that would interfere with the wound-healing process or that contraindicate the surgical procedure;
  • Pregnant or lactating women;
  • Patients who underwent periodontal surgery in the study area;
  • Patients with orthodontic therapy in progress were excluded.
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
30 participants (actual)

Study arms

  • Experimental
    Test group

    Free Gingival Graft (FGG) + Low Level Laser Therapy (LLLT) + Clinical Examination The test group received LLLT with a diode laser (CheseeTM Diode Laser, Wuhan, China ) at the FGG sites with a wavelength of 810 nm and output power of 0.1 W, for 60 s, with an energy density of 6 J/cm2 in the continuous wave mode (spot size:0.5 cm). The laser beam was directed perpendicularly toward the tissue in the noncontact mode. The laser was irradiated at the recipient sites immediately after surgery and 1, 3, 7, and 14 days later.

    Device: CheseeTM Diode Laser · Other: Clinical examination

  • Placebo comparator
    Control group

    Free Gingival Graft (FGG)+Placebo Low Level Laser Therapy (PLLLT) + Clinical Examination The control group received PLLLT with a diode laser (CheseeTM Diode Laser, Wuhan, China ) same as test group without pushing the start button

    Device: CheseeTM Diode Laser · Other: Clinical examination

Interventions

  • DeviceCheseeTM Diode Laser

    low level laser therapy was utilized adjunct with free gingival graft.

  • OtherClinical examination

    The shrinkage of the graft area was calculated according to the differences between the graft area at baseline, 1st, 3rd, and 6th months. Epithelization was determined via bubbling test by using 3% hydrogen peroxide (H2O2) at 7, 14, 21, and 28 days after surgery.

05

What researchers measure

Primary outcomes

  1. Graft shrinkage

    The shrinkage of the graft area was calculated according to the differences between the graft area at baseline, 1st, 3rd, and 6th months.

    Time frame: 1-, 3-, and 6-months after FGG surgery

Secondary outcomes

  1. Epithelization

    Epithelization was determined via bubbling test by using 3% hydrogen peroxide (H2O2). This test was carried out at 7, 14, 21, and 28 days after surgery.

    Time frame: 7, 14, 21, and 28 days after FGG surgery

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03425695
Lead sponsor
Abant Izzet Baysal University
Responsible party
Sadiye Gunpinar (Asst. Prof. Dr., Abant Izzet Baysal University) — Principal investigator
First posted
Feb 7, 2018
Start date
Jun 2016
Primary completion
Sep 2017
Completion
Sep 2017
Last update
Feb 8, 2018

Study contacts

AIBU Faculty of Dentistry
study chair · Abant Izzet Baysal University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion