An interventional study of Acacia Gum in Heart Failure, sponsored by University of Alberta. Completed at 3 sites in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-08-18.
Sponsored by University of Alberta · Not applicable, Interventional, and Treatment
FEAST-HF is a single-centre clinical trial in ambulatory patients with chronic HF to evaluate whether dietary supplementation with acacia gum reduces HF-related biomarkers NT-proBNP and ST2 and how the gut microbiome responds to dietary supplementation with acacia gum. The hypotheses of this study are 1) that changes in the gut microbiome will be correlated with a reduction in NT-proBNP and ST2 in patients with HF after treatment with acacia gum, and 2) gut microbiome configurations (composition, diversity), stability and function (gene content) will be significantly altered in patients with HF in response to acacia gum.
Exclusion Criteria:
non-fermentable active control
Dietary Supplement: Acacia Gum
fermentable dietary fiber
Dietary Supplement: Acacia Gum
fermentable dietary fiber
Dietary Supplement: Acacia Gum
dietary supplement will be added to the participant's usual diet
NT-proBNP
change in NT-proBNP level
Time frame: 12 weeks
Composite Clinical Outcomes
All cause death, hospitalizations and emergency department visits
Time frame: 12 weeks
Quality of Life
Change in quality of life assessed by the Kansas City Cardiomyopathy Questionnaire
Time frame: 12 weeks
NYHA Functional Class
Change in NYHA class treated as a categorical variable
Time frame: 12 weeks
6-Minute Walk Test
Change in 6-Minute Walk test
Time frame: 12 weeks
Fecal Microbiome Characterization
To examine the gut microbiome in a descriptive manner and characterize predominant species and those linked to Short Chain Fatty Acid production
Time frame: Baseline, Week 6, Week 12
ST-2
change in ST-2 level
Time frame: 12 weeks
Plan to share: No
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This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
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University of Alberta