An interventional study of TPN and Control in Wasting;Muscle(S), sponsored by Göteborg University. Completed at 1 site in Sweden. Open to participants aged 20 Years to 85 Years. Per ClinicalTrials.gov, last updated 2018-01-23.
Sponsored by Göteborg University · Not applicable, Interventional, and Basic science
The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.
Randomized study investigating alterations in muscle protein metabolism at provision of parenteral nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.
Exclusion Criteria:
Overnight infusion of Parenteral Nutrition supplied in all-in one bag -format. Infusion-rate of 0.16 gram Nitrogen/kg/day.
Drug: TPN
Overnight infusion of physiological saline at the same infusion-rate; ml/kg as intervention (TPN).
Other: Control
Also known as: TPN infusion
Also known as: Physiological saline infusion
Muscle protein metabolism
Alterations in muscle protein metabolism will be assessed by various standard techniques for gene and protein expression. Combined measurements of cell-signaling molecules representing anabolic and catabolic signaling pathways will be evaluated in relation to transcription of muscle myosin proteins.
Time frame: Single evaluation point at 12-14 hours following the start of overnight infusion.
This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Göteborg University