An interventional study of Butorphanol and Placebos in Agitation, sponsored by RenJi Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2020-03-10.
Sponsored by RenJi Hospital · Not applicable, Interventional, and Prevention
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Among 12 studies in Emergence Delirium by RenJi Hospital — 4 open to participants now, 4 under way, 1 of them phase 3. Emergence Delirium · RenJi Hospital.
Among the 12 studies in Emergence Delirium by RenJi Hospital, this one is the 4th largest by planned enrollment of the 11 interventional ones that give a count, is one of 2 that started in 2018, is one of 5 with no phase, and was the 3rd registered.
752 studies on the registry are indexed under Emergence Delirium; 262 are open to participants now.
Browse Emergence Delirium studies →4 of the 12 studies in Emergence Delirium by RenJi Hospital are open now, in 1 country. Recruiting first, the newest first:
RenJi Hospital · Sites in China
Ages 60+
RenJi Hospital
Ages 65+
RenJi Hospital
Ages 65–90
RenJi Hospital · Sites in China
Ages 50–85
By country, each count listing its studies:
Of the 143 Emergence Delirium studies recruiting now, 79 (55%) set no upper age limit and 44 (31%) stop at 75 or younger; 34 take children under 18; 24 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
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12 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 1 · Phase 2 1 · Phase 3 3 · Phase 4 2
First in 2016; this study’s year is marked. 2 started in 2018.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 700 is above the median of 120 across 466 interventional studies indexed under Emergence Delirium.
Median enrollment 200 across the 11 interventional studies, 211 across the 1 observational. Of the 2 that completed or were terminated, 0 (0%) have results posted.
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RenJi Hospital is the lead sponsor of 550 studies on the registry; 247 are open to participants now.
1 of the studies in Emergence Delirium by RenJi Hospital that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06653465Phase 3RenJi HospitalIntravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery | 2027-06 |
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Among the 12 studies in Emergence Delirium by RenJi Hospital, from their registry updates:
Nothing recorded among them since 2026-09-25.
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Emergence agitation is one of the common postoperative complications after functional endoscopic sinus surgery（FESS). The objective of present study is to explore the effectiveness of butorphanol in the alleviation of emergence agitation in patients undergoing Functional Endoscopic Sinus Surgery.
Butorphanol is a mixed agonist-antagonist opioid with strong κappa-receptor agonist and weak mu-receptor antagonist activity. It is commonly used for the management of cancer, postoperative, gynecologic, and obstetric pain. Additionally, Butorphanol has less respiratory depression and sedation effects, which make it may become a good medicine to alleviate the agitation. However, there is no clinical evidence to confirmation of such effectiveness of butorphanol. The objective of present study is to explore the effectiveness of butorphanol in the alleviation of emergence agitation in patients undergoing Functional Endoscopic Sinus Surgery.
752 studies on the registry are indexed under Emergence Delirium; 262 are open to participants now.
This study's planned enrollment of 700 is above the median of 120 across 466 interventional studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →RenJi Hospital is the lead sponsor of 550 studies on the registry; 247 are open to participants now.
Compared within Emergence Delirium, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Psychomotor Agitation. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Butorphanol 20ug/kg , anesthesia induction，Intravenous injection
Drug: Butorphanol
Normal saline 5ml ， anesthesia induction，Intravenous injection
Drug: Placebos
IV injection during induction
IV injection during induction
Also known as: Normal saline
Emergence agitation incidence
Emergence agitation incidence
Time frame: 1 hour in the post anesthesia care unite(PACU)
MAP
The mean arterial pressure
Time frame: 1 hour in the post anesthesia care unite(PACU)
HR
Heart rate
Time frame: 1 hour in the post anesthesia care unite(PACU)
quality of recovery -40 questionnaire
Measurement of quality of recovery with QoR-40
Time frame: 24h after operation
Started Feb 2018 (actual). Primary completion is estimated for Dec 2020, 34 months after the start.
Of 186 non-industry interventional studies with no phase under Emergence Delirium, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's planned 34 months is above that.
Counting every sponsor, half of 186 studies reached it within 19 months; a quarter within 7 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Butorphanol