An interventional study of standard care + moderate-intensity continuous exercise training and standard care + high-intensity interval training in Atrial Fibrillation, sponsored by Ottawa Heart Institute Research Corporation. Recruiting at 2 sites in Canada. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-03-11.
Sponsored by Ottawa Heart Institute Research Corporation · Not applicable, Interventional, and Other
Among 24 studies in Atrial Fibrillation by Ottawa Heart Institute Research Corporation — 7 open to participants now, 11 under way, none of them phase 3. Atrial Fibrillation · Ottawa Heart Institute Research Corporation.
Among the 24 studies in Atrial Fibrillation by Ottawa Heart Institute Research Corporation, this one is the 10th largest by planned enrollment of the 21 interventional ones that give a count, is the only one that started in 2019, is one of 18 with no phase, reaches primary completion later than 5 of the 10 other live ones, and was the 15th registered.
4,009 studies on the registry are indexed under Atrial Fibrillation; 961 are open to participants now.
Browse Atrial Fibrillation studies →7 of the 24 studies in Atrial Fibrillation by Ottawa Heart Institute Research Corporation are open now, in 2 countries. Recruiting first, the newest first:
Ottawa Heart Institute Research Corporation · Sites in Canada
Ages 18+
Ottawa Heart Institute Research Corporation · Sites in United States, Canada
Ages 18+
Ottawa Heart Institute Research Corporation · Sites in Canada
Ages 18+
Ottawa Heart Institute Research Corporation · Sites in Canada
Ages 18+
Ottawa Heart Institute Research Corporation · Sites in Canada
Ages 18+
By country, each count listing its studies:
Of the 612 Atrial Fibrillation studies recruiting now, 407 (67%) set no upper age limit and 44 (7%) stop at 75 or younger; 21 take children under 18; 43 take healthy volunteers.
This study: 40 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
24 studies; the count open now beside each. This study's row is marked.
First in 2008; this study’s year is marked. 1 started in 2019.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 132 is below the median of 150 across 2,476 interventional studies indexed under Atrial Fibrillation.
Median enrollment 102 across the 21 interventional studies, 321 across the 3 observational. Of the 13 that completed or were terminated, 2 (15%) have results posted.
This tab as a report to print or save as PDF → With an account.
Ottawa Heart Institute Research Corporation is the lead sponsor of 182 studies on the registry; 42 are open to participants now.
3 of the studies in Atrial Fibrillation by Ottawa Heart Institute Research Corporation that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT02150902Ottawa Heart Institute Research CorporationAugmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence | 2026-11-27 |
| NCT05136131Ottawa Heart Institute Research CorporationQOL Improvement After Cardioversion of Persistent AF (QOL-CAFRCT) | 2027-05 |
| NCT06556667Ottawa Heart Institute Research CorporationMAX - SHOCK Clinical Trial | 2027-09-01 |
Among the 24 studies in Atrial Fibrillation by Ottawa Heart Institute Research Corporation, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The main purpose of this project is to evaluate the effects of high-intensity interval training (HIIT) compared to moderate-intensity continuous exercise training (MICE) and standard care on exercise capacity and quality of life in patients with persistent or permanent atrial fibrillation. Positive findings are vitally important for these patients, given the condition's substantial morbidity, mortality and high economic costs.
Recommended standards of care do not include the prescription of exercise to target and ameliorate the progressive health decline and overall feeling of well-being in patients with atrial fibrillation. Recent Standards for the Provision of Cardiac Rehabilitation of Ontario are calling for the consideration for referral and enrollment of patients with atrial fibrillation in cardiovascular rehabilitation - evidence is needed to support and confirm these efforts. The main purpose of this project is to evaluate the effects of high-intensity interval training (HIIT) compared to moderate-intensity continuous exercise training (MICE) and standard care on exercise capacity and quality of life in patients with persistent or permanent atrial fibrillation. Positive results from this study will identify a new intervention that: produces important improvements in patient-rated clinical, behavioural and exercise outcomes; provides mechanistic insight into the role of exercise training in the management of atrial fibrillation; requires minimal equipment; and, is appealing to patients with atrial fibrillation.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants do not participate in a on site structured exercise training program.
standard care + moderate-intensity continuous exercise training (MICE)
Behavioral: standard care + moderate-intensity continuous exercise training
standard care + high-intensity interval training (HIIT)
Behavioral: standard care + high-intensity interval training
Participants will attend on-site moderate-intensity continuous exercise training two times weekly for 12 weeks.
Participants will attend on-site high-intensity interval training two times weekly for 12 weeks.
Changes in quality of life measured by the physical component summary (PCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36).
Changes in quality of life measured by the physical component summary (PCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36) from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes in exercise capacity measured by VO2peak on a symptom-limited cardiopulmonary exercise test (CPET).
Changes in exercise capacity measured by VO2peak on a symptom-limited cardiopulmonary exercise test (CPET) from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes atrial fibrillation specific quality of life measured by the Atrial Fibrillation Effect on Quality of Life Questionnaire (AFEQT).
Changes atrial fibrillation specific quality of life measured by the Atrial Fibrillation Effect on Quality of Life Questionnaire (AFEQT). The AFEQT assesses 4 domains: symptoms, activities, treatment concern, treatment satisfaction, and a summary score that includes the first 3 domains. Patients will assess the impact of AF on their health status during the previous 4 weeks. Responses are presented as a 7-point Likert scale. Raw scores within each domain are transformed to a 0 (most severe symptoms) to 100 scale (no limitations or disability). The AFEQT is valid, reliable and sensitive to clinical change in patients with AF undergoing different therapeutic interventions.
Time frame: baseline to 12 weeks
Changes atrial fibrillation specific quality of life measured by the University of Toronto Atrial Fibrillation Severity Scale (AFSS).
Changes atrial fibrillation specific quality of life measured by the University of Toronto Atrial Fibrillation Severity Scale (AFSS) from baseline to 12 weeks. The AFSS is a disease-specific quality of life measure used to capture subjective and objective ratings of disease burden in patients with atrial fibrillation. It assesses atrial fibrillation burden (score 1-30; higher scores indicate higher burden); Global Well Being (a visual analogue scale ranging from 1-10, indicating a patient reports as having a worst possible life \[0\] to the best possible life\[10\]); AF symptom score (score of 0-35; higher scores indicate more bothered by AF symptoms); and health care utilization (score of 0-21; higher scores indicate greater health care utilization).
Time frame: baseline to 12 weeks
Changes in symptom burden measured by the Canadian Cardiovascular Society Severity of Atrial Fibrillation Scale.
Changes in symptom burden measured by the Canadian Cardiovascular Society Severity of Atrial Fibrillation Scale from baseline to 12 weeks.The CCS-SAF is a simple, concise, symptom-based severity scale to assess patient status. CCS-SAF scores range from 0 to 4, with highest values denoting severe impact of symptoms on quality of life and activities of daily living. The CCS-SAF has been validated in patients with atrial fibrillation.
Time frame: baseline to 12 weeks
Changes in quality of life measured by the mental component summary (MCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36).
Changes in quality of life measured by the mental component summary (MCS) measure of the Short Form 36 Health Survey Questionnaire (SF-36) from baseline to 12 weeks. The SF-36 is a widely used and thoroughly validated, standardized, generic health survey with 36 questions. It yields an 8-scale (physical functioning; role-physical; bodily pain; general health; vitality; social functioning; role-emotional; and, mental health) profile of functional health and well-being scores as well as psychometrically-based physical (PCS) and mental (MCS) component summary scores.
Time frame: baseline to 12 weeks
Changes in heart rate control measured by 24-hour Holter ECG recordings and ECG recordings at each CPET.
Changes in heart rate control measured by 24-hour Holter ECG recordings and ECG recordings at each CPET from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes in lower body muscular fitness measured by standard load tests.
Changes in lower body muscular fitness measured by standard load tests from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes in volume and intensity of exercise measured directly by accelerometer.
Changes in volume and intensity of exercise measured directly by accelerometer from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes in volume and intensity of exercise measured by self-report (exercise logs).
Changes in volume and intensity of exercise measured by self-report (exercise logs) from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes in self-reported symptom frequency and severity measured by the 7-day symptom diary.
Changes in self-reported symptom frequency and severity measured by the 7-day symptom diary from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes in self reported sleep patterns measured by the 7-day sleep diary.
Changes in self reported sleep patterns measured by the 7-day sleep diary from baseline to 12 weeks.
Time frame: baseline to 12 weeks
Changes in blood biomarker concentrations (participants at the University of Ottawa Heart Institute site only).
Changes in blood biomarker concentrations from baseline to 12 weeks (participants at the University of Ottawa Heart Institute site only).
Time frame: baseline to 12 weeks
Started Jan 2019 (actual). Primary completion is estimated for Dec 2027, 107 months after the start.
Of 796 non-industry interventional studies with no phase under Atrial Fibrillation, half reached primary completion within 40 months of starting (the median), counting those still running; a quarter within 21 and three quarters within 59. This study's planned 107 months is above that.
Counting every sponsor, half of 1,051 studies reached it within 33 months; a quarter within 18 and three quarters within 54.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
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