An interventional study of 12 ml total blood tubes volume and Fecal sample in Type1diabetes, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-15.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Diagnostic
The purpose of this study is to evaluate global endocrine function within type 1 and type 3c diabetic patients, helping pancreatic polypeptide measurement.
All diabetes are the result of endrocrine deficiency. The endocrine deficiency may be absolute, as in type 1 diabetes, considered as an elective and exclusive attack of pancreatic Beta cell, or it could be relative, as un type 2 diabetes.
More rarely, diabetes fit into a broader context of pancreatic failure, with diffuse involvement of the exocrine and endocrine function, suggesting an impairment of the whole endocrine secretion of the pancreas, affecting the entire islet of Langerhans, such as in type 3c diabetes, whose prototypes are total pancreatectomy, chronic alcoholic pancreatitis, cystic fibrosis.
The diagnostic of type 3c diabetes is not always obvious, with several clinical presentations, without biological specific disease tag. Moreover, it also appears that the common form of diabetes, type 1 and type 2, may be associated with an exocrine function deficit and with a decrease of the pancreatic volume correlated with exocrine function abnormalities, and a decrease of insulin secretion capacity. The consequences of a spread of the disease beyond the Beta cells remain uncertain, but they could be linked, as in type 3c diabetes, with severe form of hypoglycaemia, due to glucagon deficiency, or nutritional deficiency due to the exocrine deficiency.
The pancreatic polypeptide belongs to the neuropeptide Y family, it is produced by the endocrine pancreatic F cells, located in the hook and the head of the pancreas. Food intake stimulates its secretion. The role of the pancreatic polypeptide in human is uncertain.
Investigators propose to study the pancreatic polypeptide in type 1 and type 3c diabetes before and after a mixed meal in order to study the other endocrine functions of the islet of Langerhans, to evaluate the possibility, or not, of a more diffuse pancreatic involvement in type 1 diabetes, considered as an elective pathology of the pancreatic Beta cell.
Exclusion Criteria:
12 ml total blood tubes volume Fecal sample
Other: 12 ml total blood tubes volume · Other: Fecal sample
12 ml total blood tubes volume Fecal sample
Other: 12 ml total blood tubes volume · Other: Fecal sample
12 ml total blood tubes volume Fecal sample
Other: 12 ml total blood tubes volume · Other: Fecal sample
12 ml total blood tubes at 0, +60, + 90, + 120 minutes before and after a mixed meal
Fecal sample at inclusion
Measurement of pancreatic polypeptide for calculating the area under the curve
physiological parameters
Time frame: 1 day
Measurement of C-peptide levels
physiological parameters
Time frame: 1 day
Measurement of fecal elastase level
physiological parameters
Time frame: at inclusion
Plan to share: No
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Assistance Publique - Hôpitaux de Paris