An observational study in Dystonia, Primary, Dysarthria and Dysphonia, sponsored by University Hospital, Lille. Completed at 1 site in France. Open to participants aged 8 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-12-21.
Sponsored by University Hospital, Lille · Observational
To better define the clinical characteristics of oromandibular dystonia, we aimed to study voice, speech and swallowing disorders in idiopathic oromandibular We planned to include consecutive patients followed in Lille Movement disorders department for idiopathic oromandibular dystonia and matched, healthy control subjects. Voice and speech disorders had to be assessed with the phonetic analysis, perceptive analysis and motor examination modules of the "Batterie d'Evaluation Clinique de la Dysarthrie" (Clinical Evaluation of Dysarthria), the Grade, Rough, Breathy, Asthenic, Strained scale, and a computer recording. Activities of daily living had to be assessed with the Oromandibular Dystonia Questionnaire, the Voice Handicap Index and the Deglutition Handicap Index.
Exclusion Criteria:
Patients with idiopathic oromandibular dystonia, either focal or associated to other dystonic features including generalized dystonia
Healthy subjects (normal neurological examination), each being age-matched to a subjet of the oromandibular dystonia group
French scale "Batterie d'Evaluation Clinique de la Dysarthrie" (Clinical Evaluation of Dysarthria) phonetic analysis.
To describe the clinical characteristics of dysarthria in idiopathic oromandibular dystonia. Composite score (min=best=0; max=worst=151) including three subscales: phonetic production (min=worst=0; max=best=33); simple words (min=worst=0; max=best=88); complex words (min=wost=0; max=best=30).
Time frame: 10 minutes at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): maximum phonation time
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Maximum phonation time was measured in seconds.
Time frame: 1 minute at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): frequency variations
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Frequency variations were measured in Hz.
Time frame: 1 minute at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): number of pauses.
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. The number of pauses was counted.
Time frame: 1 minute at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): total lecture time.
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Total lecture time was measured in seconds.
Time frame: 1 minute at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): pauses duration
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Pauses duration was measured in seconds.
Time frame: 1 minute at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): fundamental frequency
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Fundamental frequency was measured in Hz
Time frame: 1 minute at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): repetitions.
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Repetitions were measured in seconds.
Time frame: 2 minutes at baseline
French software "Logiciel d'Evaluation Vocale Assistée" (Computer-Assisted Voice Assessment): mean vocal intensity
To describe the clinical characteristics of voice impairment in idiopathic oromandibular dystonia. Mean vocal intensity was measured in dB
Time frame: 1 minute at baseline
Voice handicap index
To describe impairment of daily living activities in idiopathic oromandibular (min=best=0; max=worst=120)
Time frame: 10 minutes at baseline
Tohara swallowing test
To describe the clinical characteristics of swallowing difficulties in idiopathic oromandibular dystonia. Min=best=0; max=worst=4
Time frame: 5 minutes at baseline
Deglutition Handicap Index
To describe impairment of daily living activities in idiopathic oromandibular dystonia. Qualitative: 30 questions (possible answers: never; almost never; sometimes; often; always)
Time frame: 10 minutes at baseline
Oromandibular dystonia questionnaire
To describe impairment of daily living activities in idiopathic oromandibular dystonia. Qualitative: 25 questions (possible answers: never; almost never; sometimes; often; always)
Time frame: 10 minutes at baseline
Grade Rough Breathy Asthenic Strained scale
To describe dysphonia: from 0 (normal) to 3 (severe)
Time frame: 5 minutes at baseline
French scale "Batterie d'Evaluation Clinique de la Dysarthrie" (Clinical Evaluation of Dysarthria) phonetics characteristics
Phonetic characteristics of voice: nine items, each quoted from A (normal) to E (strongly abnormal).
Time frame: 5 minutes at baseline
French scale "Batterie d'Evaluation Clinique de la Dysarthrie" (Clinical Evaluation of Dysarthria) perceptive analysis.
To describe the clinical characteristics of dysarthria in idiopathic oromandibular dystonia. Perceptive score (min=best=0; max=worst=20)
Time frame: 5 minutes at baseline
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University Hospital, Lille