An observational study in Periprosthetic Fractures and Periprosthetic Fracture Around Prosthetic Joint Implant, sponsored by AO Innovation Translation Center. Recruiting at 13 sites in 6 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-12.
Sponsored by AO Innovation Translation Center · Observational
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty.
A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.
To close the gap of missing clinical evidence regarding the treatment of periprosthetic fractures after arthroplasty of the hip or the knee with osteosynthesis.
To drive further study hypotheses and to answer unforeseen questions.
Main questions to be answered by the registry include (but are not exclusive) the following:
Patients with total or hemi hip or knee arthroplasty and who have a fracture around one of the arthroplasty
Age ≥18 years
Post-operative PPFx after total or hemi hip or total or unicondylar knee arthroplasty (including the acetabulum, femur, patella and proximal tibia) requiring
Informed consent obtained, i.e.:
Exclusion Criteria:
Classification of the fracture
Classification of the fracture using the UCS and some parts of the AO/OTA fracture classification system.
Time frame: Pre-operatively (Day -1)
Fracture mechanism
High / low energy trauma, pathological fracture, stem stability
Time frame: Pre-operatively (Day -1)
Rehabilitation program
weight bearing, bedrest, splint
Time frame: Up to 12 months
Function of hip or knee
Harris Hip Score or Knee Society score
Time frame: Up to 12 months
Health related quality of life
PROMIS pain interference and physical activity
Time frame: Up to 12 months
Fracture healing
by RUSH or RUST score
Time frame: Up to 12 months
pain visual analog scale (VAS) and pain medication
Using the pain visual analog scale (VAS) and pain medication
Time frame: Up to 12 months
Plan to share: No
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Periprosthetic Fractures
AO Innovation Translation Center