An observational study in Periprosthetic Fractures and Periprosthetic Fracture Around Prosthetic Joint Implant, sponsored by AO Innovation Translation Center. Recruiting at 13 sites in 6 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-12.
Sponsored by AO Innovation Translation Center · Observational
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty.
A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.
To close the gap of missing clinical evidence regarding the treatment of periprosthetic fractures after arthroplasty of the hip or the knee with osteosynthesis.
To drive further study hypotheses and to answer unforeseen questions.
Main questions to be answered by the registry include (but are not exclusive) the following:
AO Innovation Translation Center is the lead sponsor of 32 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with total or hemi hip or knee arthroplasty and who have a fracture around one of the arthroplasty
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Age ≥18 years
Post-operative PPFx after total or hemi hip or total or unicondylar knee arthroplasty (including the acetabulum, femur, patella and proximal tibia) requiring
obtained, i.e.:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Classification of the fracture
Classification of the fracture using the UCS and some parts of the AO/OTA fracture classification system.
Time frame: Pre-operatively (Day -1)
Fracture mechanism
High / low energy trauma, pathological fracture, stem stability
Time frame: Pre-operatively (Day -1)
Rehabilitation program
weight bearing, bedrest, splint
Time frame: Up to 12 months
Function of hip or knee
Harris Hip Score or Knee Society score
Time frame: Up to 12 months
Health related quality of life
PROMIS pain interference and physical activity
Time frame: Up to 12 months
Fracture healing
by RUSH or RUST score
Time frame: Up to 12 months
pain visual analog scale (VAS) and pain medication
Using the pain visual analog scale (VAS) and pain medication
Time frame: Up to 12 months
Not enrolling at this site.
Plan to share: No
Started Dec 2018 (actual). Primary completion is estimated for Jan 2027, 97 months after the start.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
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Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Periprosthetic Fractures
AO Innovation Translation Center