An interventional study of Electroencephalography in Respiration Disorder, Respiratory Failure and Weaning Failure, sponsored by Poitiers University Hospital. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-07.
Sponsored by Poitiers University Hospital · Not applicable, Interventional, and Basic science
Among 29 studies in Respiration Disorders with a site in France — 4 open to participants now, 7 under way, none of them phase 3. Respiration Disorders · France.
Among the 29 studies in Respiration Disorders with a site in France, this one is the 10th largest by enrollment of the 19 interventional ones that give a count, is one of 4 that started in 2017, is one of 12 with no phase, and was the 9th registered.
359 studies on the registry are indexed under Respiration Disorders; 64 are open to participants now.
Browse Respiration Disorders studies →4 of the 29 studies in Respiration Disorders with a site in France are open now. Recruiting first, the newest first:
Nantes University Hospital · Sites in France
Ages 18–80
Assistance Publique - Hôpitaux de Paris · Sites in France
Ages 18+
Assistance Publique - Hôpitaux de Paris · Sites in France
Ages 18+
Centre Hospitalier Universitaire de Nīmes · Sites in France
Ages 18+
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 45 Respiration Disorders studies recruiting now, 27 (60%) set no upper age limit and 13 (29%) stop at 75 or younger; 15 take children under 18; 21 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
29 studies; the count open now beside each. This study's row is marked.
First in 2006; this study’s year is marked. 4 started in 2017.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 70 is close to the median of 69 across 216 interventional studies indexed under Respiration Disorders.
Median enrollment 70 across the 19 interventional studies, 170 across the 10 observational. Of the 19 that completed or were terminated, 3 (16%) have results posted.
This tab as a report to print or save as PDF → With an account.
7 of 29 have an industry lead sponsor. The 10 most frequent:
Poitiers University Hospital is the lead sponsor of 314 studies on the registry; 62 are open to participants now.
Poitiers University Hospital has 1 study filed under Respiration Disorders — fewer than ten, so there is no comparison to draw.
1 of the studies in Respiration Disorders with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07907601Centre Hospitalier Universitaire de NīmesImpact of Multidisciplinary Care, Structured and Targeted on the COPD Patient's Clinical Pathway. | 2027-11 |
Add it to your calendar (.ics) → With an account.
Among the 29 studies in Respiration Disorders with a site in France, from their registry updates:
This tab as a report to print or save as PDF → With an account.
In case of respiratory distress, patients are intubated to be connected to an artificial respirator to ensure gas exchanges. Before any ventilatory weaning, a breathing test in spontaneous ventilation under artificial nose is practiced. The patient keeps the endotracheal tube but is no longer assisted by the ventilator. Mortality is markedly increased with the prolongation of the weaning period. Despite the presence of all weaning criteria and the success of a breathing test in spontaneous ventilation under artificial nose, failure of extubation occurs in 20% of patients.
Experimental application of an additional inspiratory load in awake healthy subjects causes a compensatory increase in respiratory work to maintain effective ventilation, and the subject does not develop hypoventilation. This respiratory drive to breathe has been demonstrated by quantified electroencephalography in inspiratory load tests in the form of pre-inspiratory negative deflections of low amplitude similar to the potential described during the preparation of the voluntary movement of a limb. These inspiratory pre-motor potentials begin about 2.5 seconds before the start of a movement in the additional motor area.
Does the simple and noninvasive analysis of inspiratory cortical control during the spontaneous ventilation breath test under artificial nose predict the outcome of this test as well as weaning at 7 days?
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients extubated after the success of the breathing test in spontaneous ventilation under artificial nose and always extubated after seven days.
Device: Electroencephalography
Patients who failed the breathing test in spontaneous ventilation under artificial nose and not extubated or patients extubated after the success of the weaning test in spontaneous ventilation under artificial nose but reintubated within seven days.
Device: Electroencephalography
Simplified electroencephalography using three electroencephalogram electrodes and two electro-oculogram electrodes for the measurement of central respiratory control through the inspiratory premotor potentials.
Magnitude of Inspiratory Premotor Potentials
Amplitude in microvolts of the inspiratory premotor potentials measured during the first 15 minutes of the artificial noses breathing test in patients who successfully passed their ventilatory withdrawal and in patients who failed their withdrawal.
Time frame: Fifteen minutes
70 patients included but 62 patients could have been analyzed for technical maters
| Milestone | SBT Success | SBT Failure |
|---|---|---|
| Started | 45 | 17 |
| Completed | 45 | 17 |
| Not completed | 0 | 0 |
Amplitude in microvolts of the inspiratory premotor potentials measured during the first 15 minutes of the artificial noses breathing test in patients who successfully passed their ventilatory withdrawal and in patients who failed their withdrawal.
| µV | SBT Success | SBT Failure |
|---|---|---|
| Magnitude of Inspiratory Premotor Potentials | 1.2 (0.5 to 2.0) | 2.1 (1.7 to 2.9) |
Collected over from enrollement until the end of the spontaneous breathing trial the same day for the primary objective's mesurement and until 7 days for the whole follow up.. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| SBT Success | 0/45 (0%) | 0/45 (0%) | 0/45 (0%) |
| SBT Failure | 0/17 (0%) | 0/17 (0%) | 0/17 (0%) |
| Age, Continuous(years) | SBT Success | SBT Failure | Total |
|---|---|---|---|
| Median | 60 (56 to 67) | 70 (62 to 76) | 63 (57 to 71) |
| Sex: Female, Male(Participants) | SBT Success | SBT Failure | Total |
|---|---|---|---|
| Female | 20 | 5 | 25 |
| Male | 25 | 12 | 37 |
| Race and Ethnicity Not Collected(Participants) | SBT Success | SBT Failure | Total |
|---|---|---|---|
| Count of participants | — | — | 0 |
| Body mass index(kg/m²) | SBT Success | SBT Failure | Total |
|---|---|---|---|
| Median | 30 (26 to 34) | 32 (28 to 34) | 31 (27 to 34) |
PDFs hosted by the registry, ClinicalTrials.gov.
Ran from Feb 2017 to primary completion in Jan 2020, 35 months.
Results were first posted in Jan 2026, 5 years 11 months after primary completion.
Of 91 non-industry interventional studies with no phase under Respiration Disorders, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 37. This study's 35 months is above that.
Counting every sponsor, half of 111 studies reached it within 18 months; a quarter within 7 and three quarters within 35.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Poitiers University Hospital →