A Phase 1/2 interventional study of Hyperpolarized 129 Xenon and MRI in Respiratory Disorders, sponsored by Children's Hospital Medical Center, Cincinnati. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-14.
Sponsored by Children's Hospital Medical Center, Cincinnati · Phase 1/2, Interventional, and Diagnostic
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.
Hyperpolarized 129Xe will be produced, by trained staff, using a polarizer housed at Cincinnati Children's Hospital Medical Center. Individual imaging sessions will be done on a single day and will involve administration of (maximum) 1 liter doses for up to four MRI scans. Subject will inhale hyperpolarized xenon gas and hold breath for up to 16 seconds during the MRI scans. In addition to 129 Xe MRI, a series of anatomical conventional proton MR images may also be collected. Follow up will be done one day and 30 days from the MRI date.
359 studies on the registry are indexed under Respiration Disorders; 64 are open to participants now.
This study's planned enrollment of 100 is above the median of 69 across 216 interventional studies indexed under Respiration Disorders.
Browse Respiration Disorders studies →Children's Hospital Medical Center, Cincinnati is the lead sponsor of 673 studies on the registry; 130 are open to participants now.
Of its 57 completed or terminated interventional studies of FDA-regulated products, 31 (54%) have results posted.
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Exclusion Criteria:
Administration of up to 1 liter doses of Hyperpolarized Xenon gas during MRI to optimize acquisition of images for adults vs. proton MR imaging. These scans, utilizing volunteers for calibration, may be utilized through this study to optimize the scan details.
Drug: Hyperpolarized 129 Xenon · Device: MRI
During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans
Also known as: HP 129 Xe
Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI
quantify the measurement agreement between the ventilated volume of healthy lungs predicted via 129 Xe MRI and the ventilated volume of the pleural cavity predicted via proton MRI
Time frame: Day 1
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Studies of the drug tested here: Xenon XE-129
Children's Hospital Medical Center, Cincinnati →