An Early Phase 1 interventional study of PRP and HA in Osteoarthritis, Knee, sponsored by Cangzhou Central Hospital. Completed. Open to participants aged 40 Years to 73 Years. Per ClinicalTrials.gov, last updated 2017-11-01.
Sponsored by Cangzhou Central Hospital · Early Phase 1, Interventional, and Treatment
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP), intra-articular injection of PRP and a single application of hyaluronic acid (HA).
Methods Eighty-six patients from January 2015 to June 2015 with grade II to grade III knee osteoarthritis according to the Kellgren-Lawrence classification were randomly divided into 3 groups to receive either PRP or HA. Group A received intra-articular injection of PRP 2 ml combination with medial tibial plateau and medial femoral condyle injection of PRP 2 ml (once more 2 weeks later). Group B were treated with 2 ml of PRP intra-articular injection every 14 days for a total of two injections. Group C received intra-articular injection of hyaluronic acid 2 ml every 7 days for five injections. All patients were evaluated by the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities (WOMAC) score before the treatment and at 1st, 3rd, 6th, 12th and 18th months.
Exclusion Criteria:
injection of PRP 2 ml
Drug: PRP
injection PRP 2 ml
Drug: PRP
injection of HA 2 ml
Drug: HA
platelet rich plasma
hyaluronic acid
WOMAC scores
The evaluation was performed with WOMAC, which were recorded on a five-point Likert scale scoring, with a response of "none" scored as 0, "mild" as 1, "moderate" as 2, "severe" as 3 and "extreme" as 4.
Time frame: At the 18th month
No study locations are listed for this record.
Plan to share: Yes
No publications or documents are linked to this record.
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Cangzhou Central Hospital