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CompletedNCT03318822Updated May 6, 2021

Usability and Tolerability of Novel Protection Device Against Potential Brain Injury During Competitive Sport

An observational study in Brain Injuries, Traumatic and Brain Injury Traumatic Mild, sponsored by Emory University. Completed at 1 site in United States. Open to participants aged 14 Years to 49 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-05-06.

Sponsored by Emory University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
14 Years to 49 Years
Sex
All
01

Study summary

The purpose of the study is to assess the usability and tolerability of this jugular vein compression device in a population of helmeted and non-helmeted competitive high school, collegiate and professional athletes in the sports of football and rugby. This study differs from previous work in that it is designed to capture additional data related to the athlete experience wearing the jugular vein compression device in older and more elite playing levels.

Read the detailed description

Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from blast trauma or concussive events, would save lives, and the huge costs incurred for life-treatment of surviving victims. An externally-worn medical device that applies mild jugular compression according to the principle of the Queckenstedt Maneuver (the Device) is being developed by Q30 Sports Science, LLC (Q30). Preliminary research suggests that the Device has the potential to reduce the likelihood of TBI. The currently developed collar has been approved for studies in humans and the results indicate safety for use during high demand and maximal exertion activities. Regarding safety, the externally worn collar is meticulously designed to mimic the body's own omohyoid muscle actions upon the jugular veins that will provide similar pressure and volume increases not to surpass that of a yawn or the mere act of just lying down. This study will investigate the tolerability of this device in athletes participating in the competitive sports of football and rugby at the high school, collegiate or professional levels.

02

Conditions studied

  • Brain Injuries, Traumatic
  • Brain Injury Traumatic Mild

Keywords

  • brain injury
03

Who can participate

Ages eligible
14 Years to 49 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Normal healthy volunteers aged 14-49

Inclusion criteria

  • Normal healthy volunteer
  • Able to provide written consent
  • Must be 14 years or older and a participant in collegiate/professional sports of football or rugby

Exclusion criteria

Exclusion Criteria:

  • Unable to provide written consent
  • History of neurological deficits, previous cerebral infarction, or severe head trauma as indicated through pre-season screening:
  • Medical contraindications to restriction of venous outflow via the internal jugular veins (known increased intracerebral pressure, metabolic acidosis or alkalosis)
  • Glaucoma (Narrow Angle or Normal Tension)
  • Hydrocephalus
  • Recent penetrating brain trauma (within 6 months)
  • Known carotid hypersensitivity
  • Known increased intracranial pressure
  • Central vein thrombosis
  • Any known airway obstruction
  • Any known seizure disorder
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (actual)
Patient registry
No

Groups and cohorts

  • Q-Collar

    Subjects wearing the Q-Collar

    Device: Q-Collar

Interventions

  • DeviceQ-Collar

    An externally-worn medical device that applies mild jugular compression

05

What researchers measure

Primary outcomes

  1. Tolerability of collar usage

    measure subject tolerability to wearing the device via weekly survey

    Time frame: 1 year

Secondary outcomes

  1. Compliance of collar usage

    measure subject compliance to wearing the device via weekly survey completion

    Time frame: 1 year

06

Study locations

1 site
  • Cincinnati Childrens Hospital Medical Center
    Cincinnati, Ohio 45229, United States
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03318822
Lead sponsor
Emory University
Collaborators
Children's Hospital Medical Center, Cincinnati
Responsible party
Greg Myer (Associate Professor, Emory University) — Principal investigator
First posted
Oct 24, 2017
Start date
Aug 1, 2017
Primary completion
Jul 30, 2020
Completion
Dec 31, 2020
Last update
May 6, 2021

Study contacts

Gregory D Myer, PhD
principal investigator · Cincinnati Childrens Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2021. You cannot join it, but the record below documents what was studied.

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