CClinicalTrials.gg
Status unknownNCT03308539Updated Oct 12, 2017

Prediction of Coronary Artery Disease Severity by Epicardial Adipose Tissue Thickness

An observational study in Myocardial Infarction, sponsored by Osama Fekry. Status unknown at 1 site in Egypt. Open to participants aged Up to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-10-12.

Sponsored by Osama Fekry · Observational

The sponsor has not verified this record recently (last verified Oct 2017), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
200
Ages
Up to 90 Years
Sex
All
01

Study summary

is to test the hypotheses that epicardial adipose tissue can be a marker of severity of coronary artery disease in myocardial infarction patients

Read the detailed description

epicardial adipose tissue is defined as the adipose tissue between the visceral pericardium and the outer margin of the myocardium which can be considered an endocrine organ that secretes pro-inflammatory and anti-inflammatory cytokines and chemokines including adiponectin.as investigators know, inflammatory response is an important factor in the coronary atherogenesis. Therefore,epicardial adipose tissue is likely to be connected with the severity of coronary artery disease.Recent studies showed that the thickness of the epicardial adipose tissue in patients with coronary artery disease was greater than that with normal coronary arteries.

epicardial adipose tissue will be assessed using transthoracic echocardiography and cardiac magnetic resonance which allows for an accurate volumetric quantification of epicardial fat.

02

Conditions studied

03

Who can participate

Ages eligible
Up to 90 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

acute myocardial infarction patiens not previously underwent percutaneous coronary angiography or coronary artery bypass grafting

Inclusion criteria

  1. Normal thoracic shape
  2. Sinus rhythm
  3. without severe respiratory diseases

Exclusion criteria

Exclusion Criteria:

  1. contraindication for cardiac magnetic resonance.
  2. Patients who previously underwent coronary artery bypass grafting or percutaneous coronary angiography prior to admission
  3. history of chronic kidney disease with glomerular filtration rate \<30 mL/min
  4. pericardial and/or pleural effusion.
04

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
200 participants (estimated)
Patient registry
No

Groups and cohorts

  • myocardial infarction patients

    transthoracic echocardiography and cardiac magnetic resonance

    Radiation: echocardiography and cardiac magnetic resonance

Interventions

  • Radiationechocardiography and cardiac magnetic resonance

    transthoracic echocardiography and magnetic resonance imaging of the heart

05

What researchers measure

Primary outcomes

  1. measurement of epicardial adipose tissue as marker of severity of coronary artery disease in myocardial infarction patients.

    epicardial adipose tissue measurement using transthoracic echocardiography and cardiac magnetic resonance

    Time frame: one year

06

Study locations

1 of 1 sites recruiting
07

References and documents

Publications

  • Desferrioxamine and transfusional iron overload. Lancet. 1978 Mar 4;1(8062):479-80. No abstract available. PubMed 76025 ↗
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Registry details

Key details

Study ID
NCT03308539
Lead sponsor
Osama Fekry
Responsible party
Osama Fekry (principal investigator, Assiut University) — Sponsor-investigator
First posted
Oct 12, 2017
Start date
Nov 1, 2017 (estimated)
Primary completion
Dec 1, 2017 (estimated)
Completion
Sep 1, 2018 (estimated)
Last update
Oct 12, 2017

Study contacts

jacqueline george, master
Contact
jacquelinegeorge@yahoo.com
01275502685 ext. assiut
hosam hassan el araby, pofessor
Contact
hosam_hasan@hotmail.com
01223971327

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.

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