An interventional study of aerobic exercise and Placebo controlled group in Depressive Symptoms and Hypomania Nos Single Episode or Unspecified, sponsored by Guangzhou Psychiatric Hospital. Completed at 1 site in China. Open to participants aged 12 Years to 14 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-23.
Sponsored by Guangzhou Psychiatric Hospital · Not applicable, Interventional, and Treatment
This study will investigate the effects of aerobic exercise on mental states, cognition, and long-term outcomes in adolescents with subthreshold depressive and/or hypomanic syndromes and in non-clinical school children
Subthreshold depressive and hypomanic symptoms are common in adolescents, increasing the risk of developping into depression or bipolar disorder. Preliminary evidence shows that aerobic exercise might have positive effects in enhancing cognition and improving clinical symptoms in non-clinical and preclinical population and patients with mood disorders. This randomized controlled trial will investigate short-term (3 months) effects of aerobic exercise on cognition and clinical symptoms as well as the long-term (18 months) effects on the clinical outcomes of high-risk states.
Exclusion Criteria:
Running at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 3 months
Behavioral: aerobic exercise
6 sections of group activities: 3 sections of general psychological education; one section of group game, one section of group poetry reading activity, group singing entertainment.
Behavioral: Placebo controlled group
Running at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 3 months
6 sections of group activities: 3 sections of general psychological education; one section of group game, one section of group poetry reading activity, group singing entertainment.
Changes in depressive symptoms
Changes in depressive symptoms measured by Patient Health Questionnaire (PHQ-9)
Time frame: 12 weeks
Changes in neurocognitive function
Changes in neurocognitive function measured by the MATRICS Consensus Cognitive Battery (MCCB) after three months (12 weeks) of aerobic exercise
Time frame: 12 weeks
changes in anxious symptoms
anxious symptoms measured by Symptom Checklist 90 (SCL-90)
Time frame: 12 weeks
Changes in brain connectivity
using fMRI to measure brain connectivity
Time frame: 12 weeks
Number of participants with subthreshold mood symptoms
number of participants who meet the subthreshold syndromes for depression and/or hypomania
Time frame: 18 months
Changes in hypomanic symptoms
changes in hypomanic symptoms measured by Hypomania Check List-15(HCL-15)
Time frame: 12 weeks
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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Guangzhou Psychiatric Hospital