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CompletedNCT03298555Updated Nov 6, 2020

The HealthyMoms Trial to Promote Healthy Gestational Weight Gain

An interventional study of Mobile phone based intervention in Gestational Mothers and Weight Gain, sponsored by Karolinska Institutet. Completed at 1 site in Sweden. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-11-06.

Sponsored by Karolinska Institutet · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
305
Allocation
Randomized
Ages
18 Years and older
Sex
Female
01

Study summary

Excessive gestational weight gain is a major public health problem. Traditional face-to-face intervention programs has been shown to be succesful in order to promote healthier weight gains, however, they are time-consuming and expensive. The objectives of this study are to assess whether a 6-month smartphone application can promote healthy gestational weight gain, dietary habits and physical activity in pregnant women.

Read the detailed description

Excessive gestational weight gain (GWG) increases risks for pregnancy complications, postpartum weight retention and offspring obesity. Traditional intervention programs are time and cost intensive. Mobile technology (mHealth) has been successful for weight loss and behavior changes; however, their use in pregnancy need to be further examined. This study aims to evaluate the impact of a smartphone application (app) intervention on GWG, diet, physical activity and glucose homeostasis.

HealthyMoms is a randomized controlled trial recruiting women at the first maternity clinic visit (week 6-10) in the Linköping area, Sweden. Women will be randomized to the control or intervention group (n=150 per group). All women will receive standard care. The intervention group will also receive the HealthyMoms smartphone app promoting healthy eating, activity and GWG during 6 months. Pregnancy outcomes are GWG (primary), food intake (web-based questionnaire), fat mass (BodPod), glucose homeostasis, activity (accelerometer) in week 37. Maternal and infant body fatness will be assessed one week post partum.

02

Conditions studied

  • Gestational Mothers
  • Weight Gain
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • a single pregnancy
  • aged 18 years or above
  • be able to speak and read Swedish sufficiently well.

Exclusion criteria

Exclusion Criteria:

  • previous diagnosed eating disorder
  • pre-pregnancy diabetes or medical conditions or pharmacological treatments prior to pregnancy that may affect body weight
04

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Care provider, Investigator)
Enrollment
305 participants (actual)

Study arms

  • Experimental
    Mobile phone based intervention

    This group will receive the smartphone app HealthyMoms between gestational week 14 and 37. The app will contain information and support to achieve a healthy weight gain and lifestyle during pregnancy. This group will also receive standard care.

    Behavioral: Mobile phone based intervention

  • No intervention
    Control

    This group will only receive standard care.

Interventions

  • BehavioralMobile phone based intervention

    Participants in the intervention group will receive a 6-month mobile phone based program via a mobile phone application specifically designed for this study. The program will include information, advice and strategies to promote healthy gestational weight gain.

05

What researchers measure

Primary outcomes

  1. Gestational weight gain

    Body weight in gestational week 37 minus body weight in gestational week 14

    Time frame: At the end of the intervention which is 23 weeks after baseline

Secondary outcomes

  1. Body fatness using air-displacement plethysmography

    Body fatness in gestational week 37 minus body fatness in gestational week 14

    Time frame: At the end of the intervention which is 23 weeks after baseline

  2. Physical activity using accelerometry

    Moderate-to-vigorous physical activity (MVPA) in gestational week 37 minus MVPA in gestational week 14. MVPA will be assessed using wrist-worn accelerometry (Actigraph wGT3x) during 7 days at both time points.

    Time frame: At the end of the intervention which is 23 weeks after baseline

  3. Diet quality using a web-based questionnaire

    Diet quality in gestational week 37 minus diet quality in gestational week 14. Diet quality will be assessed using a web-based questionnaire (a combination of a food-frequency questionnaire and two 24 hour recalls)

    Time frame: At the end of the intervention which is 23 weeks after baseline

  4. Glycemia

    Plasma glucose levels in gestational week 37 minus plasma glucose levels in gestational week 14

    Time frame: At the end of the intervention which is 23 weeks after baseline

  5. Maternal body fatness post partum

    Maternal body fatness 1 week post partum

    Time frame: One week post partum

  6. Infant body fatness

    Infant body fatness at 1 week of age

    Time frame: One week of age

06

Study locations

1 site
  • Karolinska Institutet
    Stockholm, Sweden
07

References and documents

Publications

  • Sandborg J, Migueles JH, Soderstrom E, Blomberg M, Henriksson P, Lof M. Physical Activity, Body Composition, and Cardiometabolic Health during Pregnancy: A Compositional Data Approach. Med Sci Sports Exerc. 2022 Dec 1;54(12):2054-2063. doi: 10.1249/MSS.0000000000002996. Epub 2022 Sep 3. PubMed 36069838 ↗
  • Henriksson P, Migueles JH, Soderstrom E, Sandborg J, Maddison R, Lof M. User engagement in relation to effectiveness of a digital lifestyle intervention (the HealthyMoms app) in pregnancy. Sci Rep. 2022 Aug 13;12(1):13793. doi: 10.1038/s41598-022-17554-9. PubMed 35963935 ↗
  • Sandborg J, Soderstrom E, Henriksson P, Bendtsen M, Henstrom M, Leppanen MH, Maddison R, Migueles JH, Blomberg M, Lof M. Effectiveness of a Smartphone App to Promote Healthy Weight Gain, Diet, and Physical Activity During Pregnancy (HealthyMoms): Randomized Controlled Trial. JMIR Mhealth Uhealth. 2021 Mar 11;9(3):e26091. doi: 10.2196/26091. PubMed 33704075 ↗
  • Sandborg J, Henriksson P, Larsen E, Lindqvist AK, Rutberg S, Soderstrom E, Maddison R, Lof M. Participants' Engagement and Satisfaction With a Smartphone App Intended to Support Healthy Weight Gain, Diet, and Physical Activity During Pregnancy: Qualitative Study Within the HealthyMoms Trial. JMIR Mhealth Uhealth. 2021 Mar 5;9(3):e26159. doi: 10.2196/26159. PubMed 33666554 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03298555
Lead sponsor
Karolinska Institutet
Responsible party
Marie Löf, docent (Senior researcher, associate professor, Karolinska Institutet) — Principal investigator
First posted
Oct 2, 2017
Start date
Oct 1, 2017
Primary completion
Sep 30, 2020
Completion
Nov 4, 2020
Last update
Nov 6, 2020

Study contacts

Marie Löf, PhD
principal investigator · Karolinska Institutet

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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