Brain Markers of Suicide Risk and Psychological Pain in Elderly Depressed Patients

• The patient must have given their free and informed consent and signed the consent form
• be a member or beneficiary of a health insurance plan
• aged 60 years-old or more
• must be right-handed
• with a diagnosis of a current major depressive episode of moderate to severe severity according to diagnostic criteria.
• with or without a personal history of attempted suicide during life
• hospitalized or followed by a consultant in the department of Psychiatry of Nîmes University Hospital or in the Sophoras private clinic

Exclusion Criteria:

• The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
• under safeguard of justice
• refuses to sign the consent
• It is impossible to give the subject informed information
• Current psychotic symptoms.
• Bipolar disorder.
• The subject presents an acute somatic decompensation incompatible with the realization of this study.
• The patient presents a mental confusion or a known Mini Mental State Examination score \<24.
• Central neurological disease known in particular degenerative pathology, severe cranial trauma and severe cerebrovascular disease.
• Schizophrenia and other known psychotic disorders.
• Electroconvulsive therapy in the 12 months prior to study
• Inability to perform neuropsychological tests because of a language problem, poor understanding, a major tremor, inability to sit still, a major sight problem that cannot be corrected, or other severe cognitive impairment
• Contra-indication to magnetic resonance imaging (MRI): ferromagnetic implant in the body, piercing, claustrophobia, inability to remain elongated for 45 minutes.