An observational study in Cardiac Arrest, sponsored by Rennes University Hospital. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-12-27.
Sponsored by Rennes University Hospital · Observational
Objective: To assess neurologic prognostication by early Transcranial Doppler Sonography (TCD) in comatose survivors after cardiac arrest.
Design: Prospective study between May 2016 and November 2017 in a medical intensive care unit and cardiac intensive care unit in a university hospital.
Patients: all comatose patients older than 18 years successfully resuscitated from an out-of-hospital cardiac arrest (OHCA). Patients for whom OHCA is associated with traumatic brain injury, no window for TCD measurements, or dead before neurological prognostication are excluded.
The investigators measure the pulsatility index (PI) and diastolic flow velocity (DFV) of the right and left middle cerebral artery during the first 12 h after return of spontaneous circulation (ROSC). The highest value of DFV and the lowest of PI will use for the statistical analysis. Cerebral Performance Category evaluate neurologic outcome at hospital discharge.
Data provided by early TCD after ROSC are associated with neurological outcome. The use of these data could lead to the development of therapeutics improving cerebral perfusion in patient resuscitated from an OHCA.
984 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.
This study's enrollment of 52 is below the median of 196 across 394 observational studies indexed under Heart Arrest.
Browse Heart Arrest studies →Rennes University Hospital is the lead sponsor of 451 studies on the registry; 51 are open to participants now.
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Patients resuscitated from out-of-hospital cardiac arrest
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Exclusion Criteria:
Evaluate the relation between TCD measurements and neurologic outcome at hospital discharge
Good score = CPC 1-2 and bad score = CPC 3-5
Time frame: 6 months
Measurement of pulsatility index
Evaluate the association between pulsatility index and period of cardiac arrest
Time frame: 12 hours
Entry of doppler parameters
Identify a doppler parameter than can improve the neurological outcome
Time frame: 6 months
This study is completed, as verified in Dec 2019. You cannot join it, but the record below documents what was studied.
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