An interventional study of Scaling and root planing and Toluidine Blue O in Periodontitis, Chronic, Periodontal Diseases and Periodontal Bone Loss, sponsored by University of Sao Paulo. Completed at 2 sites in Brazil. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2023-02-27.
Sponsored by University of Sao Paulo · Not applicable, Interventional, and Treatment
Among 24 studies in Chronic Periodontitis with a site in Brazil — none open to participants now, 1 under way, none of them phase 3. Chronic Periodontitis · Brazil.
Among the 24 studies in Chronic Periodontitis with a site in Brazil, this one is the 17th largest by enrollment of the 23 interventional ones that give a count, is one of 2 that started in 2017, is one of 15 with no phase, and was the 19th registered.
377 studies on the registry are indexed under Chronic Periodontitis; 21 are open to participants now.
Browse Chronic Periodontitis studies →None of the 24 studies in Chronic Periodontitis with a site in Brazil is open now.
Of the 13 Chronic Periodontitis studies recruiting now, 7 (54%) set no upper age limit and 5 (38%) stop at 75 or younger; 0 take children under 18; 4 take healthy volunteers.
This study: 18 Years to 70 Years · all sexes · no healthy volunteers.
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24 studies; the count open now beside each. This study's row is marked.
First in 2002; this study’s year is marked. 2 started in 2017.
This study's enrollment of 25 is below the median of 46 across 307 interventional studies indexed under Chronic Periodontitis.
Median enrollment 44 across the 23 interventional studies, 90 across the 1 observational. Of the 19 that completed or were terminated, 0 (0%) have results posted.
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None of the 24 has an industry lead sponsor. The 10 most frequent:
University of Sao Paulo is the lead sponsor of 1,035 studies on the registry; 95 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
University of Sao Paulo has 8 studies filed under Chronic Periodontitis — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 24 studies in Chronic Periodontitis with a site in Brazil, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The aim of this study is to evaluate the additional effect of antimicrobial photodynamic therapy regeneration treatment of mandibular furcation lesions when associated to bovine bone and porcine collagen membrane.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Decontamination of furcation defect with scaling and root planing only.
Procedure: Scaling and root planing
Decontamination of furcation defect with scaling and root planing complemented by antimicrobial photodynamic therapy.
Procedure: Scaling and root planing · Drug: Toluidine Blue O
Furcation treatment by scaling and root planing
Antimicrobial photodynamic therapy with toluidine blue O (10mg/ml) and red laser.
Also known as: Antimicrobial photodynamic therapy
Horizontal probing depth
Measured with a periodontal probe (mm). Ideal if 0.
Time frame: one year
Tomographic Bone filling
Complete filling of furcation defect in tomographic images. Ideal is a radiopaque image similar to neighbor bone.
Time frame: One year
Probing depth
Distance from gingival margin to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if \< 2 mm.
Time frame: one year
Clinical Attachment Level
Distance from cemento-enamel junction to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if \< 2 mm.
Time frame: one year
Bleeding on probing
Visual confirmation of bleeding after probing. Ideal if not bleeding.
Time frame: One year
Plan to share: No
Ran from Apr 2017 to primary completion in Dec 2018, 20 months.
Of 88 non-industry interventional studies with no phase under Chronic Periodontitis, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 24. This study's 20 months is above that.
Counting every sponsor, half of 89 studies reached it within 15 months; a quarter within 10 and three quarters within 24.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Tolonium Chloride