An observational study in Seminomas, sponsored by Centre Hospitalier Universitaire Dijon. Completed at 1 site in France. Open to male participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Centre Hospitalier Universitaire Dijon · Observational
Bruno C, Blagoskonov O, Barberet J, Guilleman M, Daniel S, Tournier B, Binquet C, Choux C, Fauque P. Sperm imprinting integrity in seminoma patients? Clin Epig…PubMed 30340650 ↗
Recent data suggest that sperm cells carry an epigenetic message during spermatogenesis and that this message is crucial for the future development of the embryo. This epigenetic signature is notably represented by methylation of genes subjected to imprinting (GSI) and the methylation of transposable elements (TE). Data on the maintenance of the imprint and of the control of TE accompanying human gametogenesis in a context of adult germinal testicular cancers, seminomas, are extremely fragmentary for tumour tissues and inexistent for gametes.
The aim of this study is to determine whether patients with seminomas in comparison with fertile men carry a higher risk of presenting epigenetic alterations affecting their gametes.
This study is based on the use of an existing collection of biological samples. 90 samples will be selected and split into 3 groups:
After treatment of the samples (thawing, cell sorting and removal of cryoprotectants), they will be analysed.
63 studies on the registry are indexed under Seminoma; 15 are open to participants now.
Browse Seminoma studies →Centre Hospitalier Universitaire Dijon is the lead sponsor of 499 studies on the registry; 103 are open to participants now.
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seminomas
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hepatitis B is a virus that infects the liver. These are separate tests: HBsAg positive usually means a current infection (a recent vaccination can briefly cause it too); total anti-HBc (HBcAb) positive means an infection now or in the past; HBV DNA measures how much virus is in the blood.
Some studies accept a past infection if HBV DNA is undetectable, sometimes with antiviral medicine during the study. Check what this study allows.
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Hepatitis B tests
Hepatitis B is a virus that infects the liver. These are separate tests: HBsAg positive usually means a current infection (a recent vaccination can briefly cause it too); total anti-HBc (HBcAb) positive means an infection now or in the past; HBV DNA measures how much virus is in the blood.
Some studies accept a past infection if HBV DNA is undetectable, sometimes with antiviral medicine during the study. Check what this study allows.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Extraction genomic DNA · Other: Analysis of methylation profiles of numerous GSI and TE · Other: Analysis of methylation for the whole genome (sub-population of 15 samples from group 1) · Other: Method of protein detection by immunostaining and flow cytometry
Other: Extraction genomic DNA · Other: Analysis of methylation profiles of numerous GSI and TE · Other: Method of protein detection by immunostaining and flow cytometry
Other: Extraction genomic DNA · Other: Analysis of methylation profiles of numerous GSI and TE · Other: Method of protein detection by immunostaining and flow cytometry
Analysis of methylation profiles in paternal genes subjected to imprinting (GSI)
Time frame: at baseline
Ran from Sep 2016 to primary completion in Sep 2017, 12 months.
How these figures are worked out, and which studies are left out of them.
Bruno C, Blagoskonov O, Barberet J, Guilleman M, Daniel S, Tournier B, Binquet C, Choux C, Fauque P. Sperm imprinting integrity in seminoma patients? Clin Epig…PubMed 30340650 ↗
Bruno C, Blagoskonov O, Barberet J, Guilleman M, Daniel S, Tournier B, Binquet C, Choux C, Fauque P. Sperm imprinting integrity in seminoma patients? Clin Epig…PubMed 30340650 ↗
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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