An interventional study of Sleep Enhancement and Health Education in Prehypertension and Hypertension, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-16.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Treatment
Hypertension is the major risk factor for cardiovascular and cerebrovascular diseases worldwide. The escalating prevalence of inadequate sleep now parallels that of hypertension. Observational and experimental evidence favoring a causal relation between insufficient sleep and hypertension are particularly compelling - sleeping 6 hours or less per night is associated with a 20-32% higher probability of incident hypertension. Since sleep curtailment is largely voluntary, sleep deficiency may be corrected and the detrimental health consequences potentially reversed.
In this study the investigators aim to investigate the effects of 8 weeks of sleep enhancement/extension vs health education in prehypertensive and stage 1 hypertensive subjects who report habitual short sleep (≤6.5 hours/night).
Exclusion criteria:
Behavioral: Sleep Enhancement
Behavioral: Health Education
This regimen combines education and behavioral skills to enable prolonging sleep in chronically sleep deprived subjects so as to better meet participant's sleep needs. This intervention emphasizes plain language communication of cognitive behavioral therapy strategies for initiating and maintaining health behavior change, primarily through using brief action plans (time-limited, personally relevant, behavioral goal setting with confidence), and collaborative problem-solving. Coaching will be provided to modify daily routines and adhere to sleep hygiene practices to allow for extended time in bed.
This is a placebo/attention control condition. Participants will receive health education based on NIH information. Number, duration, and frequency of sessions will be identical to those administered to the intervention group.
change in 48-hour mean arterial pressure
changes in ambulatory measure of blood pressure
Time frame: 8 weeks
changes in 48-hour heart rate
changes in 24-hour heart rate
Time frame: 8 weeks
changes in baroreflex sensitivity
changes in baroreflex sensitivity
Time frame: 8 weeks
changes in endothelial function
changes in endothelial function
Time frame: 8 weeks
changes in renin
changes in renin
Time frame: 8 weeks
changes in angiotensin peptides
changes in angiotensin peptides
Time frame: 8 weeks
changes in aldosterone
changes in aldosterone
Time frame: 8 weeks
changes in insulin sensitivity
changes in insulin sensitivity
Time frame: 8 weeks
changes in cortisol
changes in cortisol
Time frame: 8 weeks
changes in body fat
changes in body fat
Time frame: 8 weeks
changes in catecholamines
changes in catecholamines
Time frame: 8 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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