An observational study in Hepatocellular Carcinoma and Hepatitis C, sponsored by Karolinska Institutet. Completed at 1 site in Sweden. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-02-18.
Sponsored by Karolinska Institutet · Observational
In this international collaboration study, the research group will analyze somatic mutations of hepatocellular carcinoma (HCC) developed after sustained virological response (SVR) in patients treated with hepatitis C (HCV) therapy
Method Paired liver tissue samples will be collected from the tumour sections and also from the adjacent non-tumour tissues, for comparison in each individual. The tissues have been collected as part of routine clinical work/other studies, by liver biopsies or at liver resection/liver transplantation. Data regarding the patient characteristic will be collected. Whole genome sequencing analyses are planned to be performed.
Please see eligibility criteria
Exclusion Criteria:
HCV patients with SVR and developed HCC plus available tissue from HCC
Characterisation of genomic mutations of HCC, developed in HCV patients with SVR
Genetic characteristics of HCCs will be compared to non-HCC tissue
Time frame: 5 years
Plan to share: No — Individual IPD will not be shared with other researchers
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This study is completed, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.
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Karolinska Institutet