VX-770 for the Treatment of Chronic Bronchitis

• Male or Female age 18 years
• A Clinical diagnosis of Bronchiectasis and/or Chronic Bronchitis in the investigators opinion
• Exhibit symptoms of chronic bronchitis as defined by the Medical Research Council
• FEV1 percent predicted greater than 40 percent Post Bronchodilator
• Clinically stable in the last 4 weeks with no evidence of exacerbation
• Weight of 40 kg to120 kg
• Willingness to use at least one form of acceptable birth control including abstinence, condom with spermicide, or hormonal contraceptives
• Willing to monitor blood glucose if known history of diabetes mellitus requiring insulin or medical therapy
• Element of CFTR Dysfunction, as defined by Sweat Chloride

Exclusion

• Daytime use of Oxygen Therapy
• Documented history of drug abuse within the last year
• Subjects should not have a pulmonary exacerbation or changes in therapy for pulmonary disease within 28 days before receiving the first dose of study drug.
• Cirrhosis or elevated liver transaminases > 3X ULN
• GFR \< 50 estimated by Cockroft-Gault
• Any illness or abnormal lab finding that, in the opinion of the investigator might confound the results of the study or pose an additional risk in administering study drug to the subject.
• Pregnant or Breastfeeding
• Subjects taking any inhibitors or inducers of CYP3A4, including certain herbal medications and grapefruit juice. (Excluded medications and foods including the drugs and foods are provided in the appendix document)
• Uncontrolled Diabetes
• Clinically significant arrhythmias or conduction abnormalities that in the opinion of the investigator that affect patient safety