An observational study in Atherosclerosis, Stroke and Inflammation, sponsored by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau. Status unknown at 1 site in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-07-14.
Sponsored by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Observational
Ischemic stroke is a leading cause of death and disability worldwide. Atherosclerosis, responsible for the 20% of ischemic strokes, is characterized by lipid accumulation in the artery wall that leads to chronic inflammation, cell proliferation and ultimately to vessel stenosis. One of the main features related to plaque progression and vulnerability is inflammation. Positron emission tomography with 18-fluorodeoxyglucos (18-FDG PET) allows an accurate quantification of plaque inflammation and it has been proved its usefulness in predicting early stroke recurrences. The investigators aim to test how modifiable vascular risk factors influence plaque inflammation assessed by 18-FDG PET. In addition, investigators will assess the association of this inflammation and circulating endothelial progenitor cells
1,567 studies on the registry are indexed under Atherosclerosis; 265 are open to participants now.
This study's planned enrollment of 120 is below the median of 223 across 571 observational studies indexed under Atherosclerosis.
Browse Atherosclerosis studies →Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau is the lead sponsor of 335 studies on the registry; 64 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients diagnosed of ischemic stroke presenting at least on atherosclerotic plaque in the internal carotid artery ipsilateral to stroke
Exclusion Criteria:
Change in the Standardized Uptake Value (SUV) of the internal carotid artery
Inflammation change of the internal carotid artery assessed by the Standardized Uptake Value (SUV) obtained with 18FDG-PET scan at one-year follow-up
Time frame: Baseline and at one year follow-up
Change in the Target-to-Background Ratio (TBR) of the internal carotid artery
Inflammation change of the internal carotid artery assessed by the Target-to-Background Ratio (TBR) obtained with 18FDG-PET scan at one-year follow-up
Time frame: Baseline and at one year follow-up
Change in the Endothelial Progenitor Cells Count
Change in the Endothelial Progenitor Cells Count by flow cytometry
Time frame: Baseline and at one year follow-up
Plan to share: No
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This study is status unknown, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.
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Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau