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CompletedNCT03217721REANEUFUpdated Aug 12, 2024

Antibiotics Management of Septic Neutropenic Patients in the Intensive Care Unit

An observational study in Neutropenia, Febrile, sponsored by University Hospital, Brest. Completed at 1 site in France. Per ClinicalTrials.gov, last updated 2024-08-12.

Sponsored by University Hospital, Brest · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
130
Sex
All
01

Study summary

Neutropenia, defined by an absolute count of polymorphonuclear neutrophils less than \<1500/mm3, exposes patients to infectious complications that can lead to sepsis or septic shock. The mortality risk is higher risk. The recommendations published in 2016 were formulated to homogenize the clinical practices to improve the survival.

Read the detailed description

We evaluate the adequacy antibiotics prescriptions in febrile neutropenia with suspected infection and evaluate factors influencing adequacy therapy and mortality consequence.

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Conditions studied

  • Neutropenia, Febrile
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In context

Neutropenia

396 studies on the registry are indexed under Neutropenia; 57 are open to participants now.

This study's enrollment of 130 is below the median of 175 across 96 observational studies indexed under Neutropenia.

Browse Neutropenia studies →

Lead sponsor

University Hospital, Brest is the lead sponsor of 594 studies on the registry; 135 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Pilot, exploratory, monocentric, retrospective, observational study

Inclusion criteria

  • Sepsis or septic shock at admission or during the stay

Exclusion criteria

Exclusion Criteria:

  • Minor
  • Pregnancy
  • Opposition
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
130 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Proportion of adequate antibiotic prescription

    Proportion of adequate antibiotic prescription

    Time frame: Through study completion, an average of 1 month

Secondary outcomes

  1. Mortality of all causes

    Mortality of all causes

    Time frame: ICU, hospital and 28-day mortality

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Study locations

1 site
  • CHRU de Brest
    Brest, 29609, France
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References and documents

Publications

  • Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF). Ann Intensive Care. 2016 Dec;6(1):90. doi: 10.1186/s13613-016-0189-6. Epub 2016 Sep 15. PubMed 27638133 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 12, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03217721
Lead sponsor
University Hospital, Brest
Responsible party
Sponsor
First posted
Jul 14, 2017
Start date
Jun 19, 2017
Primary completion
Sep 19, 2017
Completion
Sep 19, 2017
Last update
Aug 12, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.

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Discussion

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