An observational study in Knee Osteoarthritis, sponsored by University Hospital, Grenoble. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-09-11.
Sponsored by University Hospital, Grenoble · Observational
Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.
Knee osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration. This observationnal, pilot, prospective, non randomized, uncontrolled, monocentric study aim to compare three of the most innovative imaging systems, namely the 9,4 Tesla MRI, the FFOCT (Full-Field Optical Coherence Tomography) and the ultrasound-based navigation system in order to image healthly to severely degraded human cartilage samples. All methods will be cross-correlated and compared with histological data considered as the gold standard.
3,391 studies on the registry are indexed under Osteoarthritis, Knee; 628 are open to participants now.
This study's enrollment of 10 is below the median of 100 across 484 observational studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →University Hospital, Grenoble is the lead sponsor of 835 studies on the registry; 207 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with knee arthroplasty indication for medial femoro-tibial osteoarthristis at University Hospital, Grenoble
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Exclusion Criteria:
All subject of the study have a knee osteoarthritis (OA) and are going to have a knee prosthetic surgery with cartilage excision. Multimodal evaluation is conducted on ex vivo human cartilage samples (2 samples per patient are selected : healthy and severely degraded).
Evaluation and comparison of histologic analysis, 9,4 Tesla MRI, FFOCT and ultrasound-based navigation system for cartilage lesions analysis of patellofemoral joint.
Correlation between Osteoarthritis Research Society International (OARSI) grades performed for different modalities
Time frame: 6 months
Evaluation of 9,4 Tesla MRI reconstructions in early osteoarthritis evaluation using visual qualitative information parameter obtained from the Average Pathlength Maps (APM).
Correlation between MRI quantitative parameters and gold standard OARSI grade
Time frame: 6 months
Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual qualitative information parameter.
Correlation between quantitative parameters from FFOCT and gold standard OARSI grade
Time frame: 6 months
Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual qualitative information parameter.
Correlation between quantitative parameters from navigation ultrasound and gold standard OARSI grade
Time frame: 6 months
Evaluation of of 9,4 Tesla MRI reconstruction in early osteoarthritis evaluation using visual quantitative information parameter obtained for the Average Pathlength Maps.
Correlation between quantitative parameters from the Average Pathlength Maps and gold standard OARSI grade
Time frame: 6 months
Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual quantitative information parameter.
Thickness average of cartilage
Time frame: 6 months
Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual quantitative information parameter.
Roughness average of cartilage
Time frame: 6 months
Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual quantitative information parameter.
Thickness average of cartilage
Time frame: 6 months
Inter-observer robustness analysis of the OARSI classification
Inter-observers Kappa coefficient
Time frame: 6 months
Intra-observer robustness analysis of the OARSI classification
Intra-observers Kappa coefficient
Time frame: 6 months
Plan to share: No
This study is completed, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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