An interventional study of Platelet-rich plasma in Osteo Arthritis Knee and Platelet-rich Plasma, sponsored by Pei-Yuan Lee, MD. Completed at 1 site in Taiwan. Open to participants aged 30 Years to 70 Years. Per ClinicalTrials.gov, last updated 2019-09-06.
Sponsored by Pei-Yuan Lee, MD · Not applicable, Interventional, and Treatment
This study aimed to analyze the effect of platelet-rich plasma (PRP) on knee osteoarthritis. Eligible patients will undertake arthroscopic knee surgery plus intraoperative PRP and also receive second look surgery and intraoperative biopsy.
Osteoarthritis is a chronic disease defined by progressive degradation of the joint as well as loss of cartilage on joint surfaces. The degeneration that occurs in the joint leads to changes in the catabolic and anabolic activity of chondrocytes. Osteoarthritis may induce pain, stiffness and limitation in range of motion of the joint and also may impact the quality of life. Platelet-rich plasma (PRP) is a fraction of plasma that contains platelets and multiple growth factors concentrated at high level. Because activated platelets have the potential to release growth factors, PRP has been clinically used to accelerate wound healing and tissue regeneration in orthopedic and oral surgery. Although several studies have assessed the effects of PRP on knee osteoarthritis, a higher level of evidence has not been provided. This study aimed to analyze the effect of PRP on knee osteoarthritis. After performing arthroscopic knee surgery plus intraoperative PRP in eligible patients, a second look arthroscopic surgery with intraoperative biopsy will be arranged 6 months later. Pre- and post-operative imaging and clinical outcomes will also be compared.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's enrollment of 12 is below the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →Pei-Yuan Lee, MD is the lead sponsor of 8 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Arthroscopic knee surgery plus intraoperative platelet-rich plasma
Other: Platelet-rich plasma
Intraoperative platelet-rich plasma injection during arthroscopic knee surgery
Change in knee function from baseline to postoperative 3 months
Knee function is evaluated using Oswestry Disability Index preoperatively and 3-month postoperatively.
Time frame: 3-month postoperative
Change in knee function from baseline to postoperative 6 months
Knee function is evaluated using Oswestry Disability Index preoperatively and 6-month postoperatively.
Time frame: 6-month postoperative
Change in knee function from baseline to postoperative 12 months
Knee function is evaluated using Oswestry Disability Index preoperatively and 12-month postoperatively.
Time frame: 12-month postoperative
Change in knee pain from baseline to postoperative 3 months
Pain is evaluated using visual analogue scale preoperatively and 3-month postoperatively.
Time frame: 3-month postoperative
Change in knee pain from baseline to postoperative 6 months
Pain is evaluated using visual analogue scale preoperatively and 6-month postoperatively.
Time frame: 6-month postoperative
Change in knee pain from baseline to postoperative 12 months
Pain is evaluated using visual analogue scale preoperatively and 12-month postoperatively.
Time frame: 12-month postoperative
Percentage of patients with regenerated cartilage
Cartilage regeneration is assessed by pathological biopsy during second look surgery at 12-month postoperative.
Time frame: 12-month postoperative
Change in cartilage thickness from baseline to postoperative 6 months
Cartilage thickness is assessed by MRI preoperatively and 6-month postoperatively.
Time frame: 6-month postoperative
Plan to share: No
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This study is completed, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.
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Pei-Yuan Lee, MD