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CompletedNCT03184636ACLFUpdated Aug 14, 2018

Acute-On-Chronic Liver Failure in Zagazig University Hospitals

An observational study in Acute-On-Chronic Liver Failure, sponsored by Zagazig University. Completed at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2018-08-14.

Sponsored by Zagazig University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
300
Sex
All
01

Study summary

Rationale:

To identify the prevalence of Acute-on-chronic liver failure in Zagazig University Hospitals.

The question of the research:

How much the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals?

The aim of the work:

The aim of the study is to identify the presence of Acute-on-chronic Liver Failure in Zagazig University Hospitals

Objectives:

To estimate the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals.

Subjects and Methods:

I . Technical Design:

  • Site of the study: Gastroenterology and Hepatology Unit- Zagazig University Hospitals
  • Sample size: ''all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD from June 2017 to December 2017 were included in this study''.

II . OPERATIONAL DESIGN:

  • Type of the study: a prospective study.
  • Full medical history - taking.
  • Full clinical examination.
  • Laboratory investigations including Routine laboratory investigation " CBC, Liver functions test, kidney functions test and prothrombin time "

III. Administrative Design:

  • Approvals obtained for performing the study from the official or governmental department.
  • An ethical committee from the faculty of medicine and patients included in the study.

Results:

Collected data will be presented in tables and suitable graphs and analyzed according to standard statistical methods

02

Conditions studied

  • Acute-On-Chronic Liver Failure

Keywords

  • ACLF
  • SOFA
  • Zagazig university
03

In context

Liver Failure

445 studies on the registry are indexed under Liver Failure; 69 are open to participants now.

This study's enrollment of 300 is above the median of 129 across 146 observational studies indexed under Liver Failure.

Browse Liver Failure studies →

Lead sponsor

Zagazig University is the lead sponsor of 447 studies on the registry; 75 are open to participants now.

Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

All patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Inclusion criteria

  • all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Exclusion criteria

Exclusion Criteria:

  • no any exclusion criteria
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
300 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. improvement of the patients score according to SOFA score (AASLD and EASL guidelines)

    follow up of participants until the patients recover

    Time frame: 24 weeks from first recruiting

Secondary outcomes

  1. death of the patient

    due to the severity of acute on chronic failure, the death of patients is expected

    Time frame: 24 weeks from first recruiting

07

Study locations

1 site
  • Salem Mohamed
    Zagazig, Sharqia 44519, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 14, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03184636
Lead sponsor
Zagazig University
Responsible party
salem youssef mohamed (assistant professor of internal medicine, gastroenterology and hepatology unit, Zagazig University) — Principal investigator
First posted
Jun 12, 2017
Start date
Jul 1, 2017
Primary completion
Aug 11, 2018
Completion
Aug 11, 2018
Last update
Aug 14, 2018

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.

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