CClinicalTrials.gg
CompletedNCT03135600Updated May 30, 2017

The Influence of Running to ACL Deficiency

An interventional study of Procedure in ACL Injury and Gait, sponsored by Guangzhou General Hospital of Guangzhou Military Command. Completed at 1 site in China. Open to participants aged 20 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-05-30.

Sponsored by Guangzhou General Hospital of Guangzhou Military Command · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
20 Years to 30 Years
Sex
All
01

Study summary

The aim of this study is to investigate the influence of running to kinematic parameters of patients with anterior cruciate ligament.

02

Conditions studied

  • ACL Injury
  • Gait

Keywords

  • Knee
  • ACL Injury
  • Kinematics
03

In context

Anterior Cruciate Ligament Injuries

511 studies on the registry are indexed under Anterior Cruciate Ligament Injuries; 163 are open to participants now.

This study's enrollment of 60 is close to the median of 56 across 372 interventional studies indexed under Anterior Cruciate Ligament Injuries.

Browse Anterior Cruciate Ligament Injuries studies →

Lead sponsor

Guangzhou General Hospital of Guangzhou Military Command is the lead sponsor of 46 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  1. 20\< age \< 30.
  2. Body mass index \< 30.
  3. For controls, no history of major injury or surgery in lower limbs; no symptoms of lower limbs; physical examination to test the lower limbs to be healthy.
  4. For ACLD group, history of knee injury for at least 2 weeks and able to walk and run; confirmed to be unilateral ACL injury by MRI; knee pain in the knee (ACL injury).
  5. The habit of moderate exercise (e.g. Jogging) at least once a week for at least 30 minutes.

Exclusion criteria

Exclusion Criteria:

  1. Body mass index >30.
  2. For controls, injury or surgery in hip/knee/ankle.
  3. For ACLD group, injury or surgery in hip/ankle; confirmed to be no ACL injury by arthroscopy.
  4. Neuropathic disease.
  5. Muscular disease.
  6. Lack ability to finish the procedure physically or mentally.
  7. Easy to fall.
  8. Any other conditions that can influence gait parameters of the lower limbs.
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Factorial assignment
Masking
Single (Outcomes assessor)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    Normal

    The participants from this group are healthy people.

    Procedure: Procedure

  • Experimental
    ACLD

    The participants from this group suffer from anterior cruciate ligament injury.

    Procedure: Procedure

Interventions

  • ProcedureProcedure

    Once participants are eligible, they will undergo the experimental procedure. Before data collection, they will walk on a treadmill in barefoot for ten minutes to adapt the condition. The a gait analysis system will collect the data while they walk/run on the treadmill in barefoot at 4/6km/h.

06

What researchers measure

Primary outcomes

  1. Knee flexion/extension angle at initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  2. Knee internal/external rotation angle at initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  3. Knee adduction/abduction angle at initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  4. Knee anterior/posterior translation at initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  5. Knee medial/lateral translation at initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  6. Knee proximal/distal translation at initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  7. Knee flexion/extension angle at opposite toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  8. Knee adduction/abduction angle at opposite toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  9. Knee internal/external rotation angle at opposite toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  10. Knee anterior/posterior translation at opposite toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  11. Knee distal/proximal translation at opposite toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  12. Knee medial/lateral translation at opposite toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  13. Knee flexion/extension angle at heel rise during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  14. Knee internal/external rotation angle at heel rise during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  15. Knee adduction/abduction angle at heel rise during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  16. Knee anterior/posterior translation at heel rise during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  17. Knee distal/proximal translation at heel rise during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  18. Knee medial/lateral translation at heel rise during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  19. Knee flexion/extension angle at opposite initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  20. Knee adduction/abduction angle at opposite initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  21. Knee internal/external rotation angle at opposite initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  22. Knee anterior/posterior translation at opposite initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  23. Knee distal/proximal translation at opposite initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  24. Knee medial/lateral translation at opposite initial contact during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  25. Knee flexion/extension angle at toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  26. Knee adduction/abduction angle at toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  27. Knee internal/external rotation angle at toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  28. Knee anterior/posterior translation at toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  29. Knee distal/proximal translation at toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  30. Knee medial/lateral translation at toe off during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  31. Knee flexion/extension angle at feet adjacent during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  32. Knee internal/external rotation angle at feet adjacent during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  33. Knee adduction/abduction angle at feet adjacent during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  34. Knee anterior/posterior translation at feet adjacent during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  35. Knee distal/proximal translation at feet adjacent during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  36. Knee medial/lateral translation at feet adjacent during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  37. Knee flexion/extension angle at tibial vertical during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  38. Knee adduction/abduction angle at tibial vertical during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  39. Knee internal/external rotation angle at tibial vertical during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  40. Knee anterior/posterior translation at tibial vertical during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  41. Knee distal/proximal translation at tibial vertical during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  42. Knee medial/lateral translation at tibial vertical during gait.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  43. Range of motion of knee flexion/extension angle.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  44. Range of motion of knee adduction/abduction angle.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  45. Range of motion of knee internal/external rotation angle.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  46. Range of motion of knee anterior/posterior translation.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  47. Range of motion of knee distal/proximal translation.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

  48. Range of motion of knee medial/lateral translation.

    The gait cycle include seven key events (e.g. initial contact), and each gait has six degrees of freedom, including knee flexion/extension, internal/external rotation, adduction/abduction, anterior/posterior translation, distal/proximal translation, medial/lateral translation. The unit of angle is degree and that of translation is millimetre.

    Time frame: 1 Day

07

Study locations

1 site
  • Hospital of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command
    Guangzhou, Guangdong 510010, China
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 30, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03135600
Lead sponsor
Guangzhou General Hospital of Guangzhou Military Command
Collaborators
Medical Center of Assessment, Prevention and Treatment of Bone & Joint Diseases, Guangdong, China, The First Affiliated Hospital of Guangzhou Medical University
Responsible party
Yu Zhang (chief surgeon, associate professor, Guangzhou General Hospital of Guangzhou Military Command) — Principal investigator
First posted
May 1, 2017
Start date
Apr 26, 2017
Primary completion
May 17, 2017
Completion
May 21, 2017
Last update
May 30, 2017

Study contacts

Yu Zhang, PhD
principal investigator · Hospital of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, Guangzhou 510010, China

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
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