CClinicalTrials.gg
Status unknownNCT03099837TMCHCUpdated Aug 4, 2020

Tongji Maternal and Child Health Cohort

An observational study in Weight Gain, Maternal; Diabetes Mellitus, Affecting Fetus and Diet Habit, sponsored by Huazhong University of Science and Technology. Status unknown. Open to female participants. Per ClinicalTrials.gov, last updated 2020-08-04.

Sponsored by Huazhong University of Science and Technology · Observational

The sponsor has not verified this record recently (last verified Aug 2020), so the status shown — last known as Active, not recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
8,649
Sex
Female
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Study summary

This is a population-based study to obtain data for the evaluation of current used recommendations for weight gain during pregnancy released by IOM (2007) and investigate the association between maternal diet and the health outcomes of mother and offspring.

Read the detailed description

This is an ongoing population-based prospective cohort study to obtain data for the evaluation of current used recommendations for weight gain during pregnancy released by IOM (2007) and investigate the association between maternal diet and the health outcomes of mother and offspring. 8649 pregnant have been recuited from the first trimester of pregnancy. All datas including the general information, sociodemographic facts, physical exam (body weight, height, blood pressure, etc), laboratory test (hemoglobin, glucose concentration, etc.) and dietary survey (FFQ, 24h food recall) have been collected during the cohort study. Blood sample leftover from the clinical use are remained and stored at -80℃for further measurements. Obstetric characteristics, maternal and perinatal outcomes have been observed and recorded. Growth and development paremeters such as weight, length and head circumference as well as disease information of infants have been collected , feeding pattern and feeding history will be surveyed. All data collected will be used for group analysis only and all private and individual records will be kept secret.

02

Conditions studied

  • Weight Gain
  • Maternal; Diabetes Mellitus, Affecting Fetus
  • Diet Habit
  • Pregnancy Complications
  • Birth Outcomes
  • Breast Feeding
  • Growth and Development
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In context

Pregnancy Complications

437 studies on the registry are indexed under Pregnancy Complications; 119 are open to participants now.

This study's enrollment of 8,649 is above the median of 320 across 205 observational studies indexed under Pregnancy Complications.

Browse Pregnancy Complications studies →

Lead sponsor

Huazhong University of Science and Technology is the lead sponsor of 241 studies on the registry; 60 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Female
Sampling method
Probability sample

Study population

The Tongji Maternal and Child Health enrolled healthy pregnant women at 8-16 weeks gestation when they attended their first antenatal visit at a maternity clinic in one of these following hospitals in Wuhan, China: Hubei Maternal and Child Health Hospital (HMCHH), The Central Hospital of Wuhan(CHW), Wuhan Maternal and Child Health Hospital (WMCHH), Jiang'an Maternal and Child Health Hospital(JMCHH). Babies born from these mothers will be followed up until the child is at least 10 years of age.

Inclusion criteria

  • Pregnant women attending the first visit (\<16 weeks ) at at a maternity clinic in one of these following hospitals in Wuhan, China: HMCHH, CHW,WMCHH,JMCHH.

Intention to visit the maternity clinic regularly in HMCHH or CHW or WMCHH or JMCHH.

  • Intention to eventually deliver in HMCHH or CHW or WMCHH.
  • The pregnant woman and her husband are Chinese.

Exclusion criteria

Exclusion Criteria:

  • Pregnant women on chemotherapy.
  • Exclude women on certain medications - e.g. psychotropic drugs.
  • Exclude women with significant medical conditions e.g. psychosis etc.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
8,649 participants (actual)
Patient registry
No

Groups and cohorts

  • Pregnant mothers
  • infants
  • children
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What researchers measure

Primary outcomes

  1. Effect of weight gain during pregnancy on maternal and child health

    To regularly measure the weight gains of pregnant women during pregnancy, and examine their association with maternal and child health.

    Time frame: During pregnancy, infancy period and childhood, assessed up to 120 months

  2. Effect of factors in pregnancy and early postpartum period on maternal health

    To examine the role of maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of metabolic disorders and even lead to complications of pregnancy, such as gestational diabetes mellitus.

    Time frame: During pregnancy and postpartum period, assessed up to 12 months

  3. Influence of prenatal and early postnatal factors on child health

    To examine the role of maternal nutrition, lifestyle, emotional health, breastfeeding, and other environmental factors in infancy that can influence the development of phenotypes in childhood which confer risk for later metabolic and mental disorders.

    Time frame: During pregnancy, infancy period and childhood, assessed up to 120 months

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Zhong C, Xiong G, Lin L, Li Q, Chen X, Zhang X, Zhang Y, Xu S, Wang X, Gao D, Wu M, Yang S, Han W, Sun G, Yang X, Hao L, Jin Z, Yang N. The association of maternal vaginal bleeding and progesterone supplementation in early pregnancy with offspring outcomes: a prospective cohort study. BMC Pregnancy Childbirth. 2022 May 5;22(1):390. doi: 10.1186/s12884-022-04711-1. PubMed 35513779 ↗
  • Li Y, Zhou X, Zhang Y, Zhong C, Huang L, Chen X, Chen R, Wu J, Li Q, Sun G, Yin H, Xiong G, Hao L, Yang N, Yang X. Association of Maternal Dietary Patterns With Birth Weight and the Mediation of Gestational Weight Gain: A Prospective Birth Cohort. Front Nutr. 2021 Nov 26;8:782011. doi: 10.3389/fnut.2021.782011. eCollection 2021. PubMed 34901129 ↗
  • Xiong T, Wu Y, Huang L, Chen X, Zhang Y, Zhong C, Gao Q, Hong M, Hu X, Yang X, Yang N, Hao L. Association of the maternal serum albumin level with fetal growth and fetal growth restriction in term-born singletons: a prospective cohort study. Fertil Steril. 2022 Feb;117(2):368-375. doi: 10.1016/j.fertnstert.2021.09.016. Epub 2021 Oct 20. PubMed 34686372 ↗
  • Gao Q, Zhong C, Zhou X, Chen R, Xiong T, Hong M, Li Q, Kong M, Xiong G, Han W, Sun G, Yang X, Yang N, Hao L. Inverse association of total polyphenols and flavonoids intake and the intake from fruits with the risk of gestational diabetes mellitus: A prospective cohort study. Clin Nutr. 2021 Feb;40(2):550-559. doi: 10.1016/j.clnu.2020.05.053. Epub 2020 Jun 13. PubMed 32593522 ↗
  • Zhou X, Chen R, Zhong C, Wu J, Li X, Li Q, Cui W, Yi N, Xiao M, Yin H, Xiong G, Han W, Hao L, Yang X, Yang N. Fresh fruit intake in pregnancy and association with gestational diabetes mellitus: A prospective cohort study. Nutrition. 2019 Apr;60:129-135. doi: 10.1016/j.nut.2018.09.022. Epub 2018 Oct 24. PubMed 30572275 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 4, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03099837
Lead sponsor
Huazhong University of Science and Technology
Collaborators
Maternal and Child Health Hospital of Hubei Province, Wuhan Central Hospital, Wuhan Maternal and Child Health Hospital
Responsible party
Nianhong Yang (Professor, Huazhong University of Science and Technology) — Principal investigator
First posted
Apr 4, 2017
Start date
Jan 10, 2013
Primary completion
Jan 10, 2023 (estimated)
Completion
Jan 10, 2023 (estimated)
Last update
Aug 4, 2020

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2020. You cannot join it, but the record below documents what was studied.

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