An interventional study of Intensive Periodontal Treatment and Control Periodontal Treatment in Periodontitis and Intimal Medial Thickness of Internal Carotid Artery, sponsored by University College, London. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-01-25.
Sponsored by University College, London · Not applicable, Interventional, and Treatment
The investigators wish to assess whether intensive periodontal therapy will reduce the burden of chronic periodontal disease and will cause regression or prevent progression of atherosclerosis assessed by a surrogate end-point (carotid intima-media thickness) at 24 months compared to control periodontal therapy.
1,664 studies on the registry are indexed under Periodontitis; 328 are open to participants now.
This study's enrollment of 190 is above the median of 45 across 1,206 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →University College, London is the lead sponsor of 647 studies on the registry; 145 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Procedure: Intensive Periodontal Treatment
Procedure: Control Periodontal Treatment
Common Carotid Intima-media Thickness (cIMT)
Assess whether intensive periodontal therapy will cause regression or prevent progression of atherosclerosis assessed by carotid intima-media thickness at 24 months compared to standard periodontal therapy.
Time frame: cIMT will be assessed at Baseline, 12 and 24 months after periodontal treatment
Brachial artery Flow-mediated dilatation (FMD)
Assess whether pre-treatment (24hrs before) with remote ischaemic pre-conditioning will prevent acute inflammatory endothelial dysfunction induced by intensive periodontal treatment
Time frame: FMD will be assessed at baseline, 24 hours and 1 week after periodontal treatment
Pulse-wave velocity (PWV)
Assess whether intensive periodontal therapy will cause amelioration of PWV at 12, 18 and 24 months follow up compared to standard periodontal therapy.
Time frame: PWV will be assessed at baseline, 2, 6, 12, 18 and 24 months following periodontal treatment
Brachial artery Flow-mediated dilatation (FMD)
Assess whether intensive periodontal therapy will cause amelioration of FMD at 12, 18 and 24 months follow up compared to standard periodontal therapy.
Time frame: FMD will be assessed at baseline, 2 , 6 , 12 , 18 and 24 months following periodontal treatment
Blood inflammatory markers
Assess whether intensive periodontal therapy will cause changes in the blood inflammatory markers profile at 2, 6, 12, 18 and 24 months follow up compared to standard periodontal therapy.
Time frame: Inflammatory mediators profile will be assessed at baseline, 2, 6, 12, 18 and 24 months following periodontal treatment
Oxidative stress
Assess whether intensive periodontal therapy will cause changes in the oxidative stress profile at 2, 6, 12, 18 and 24 months follow up compared to standard periodontal therapy.
Time frame: Oxidative stress profile will be assessed at baseline, 2, 6, 12, 18 and 24 months following periodontal treatment
This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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