An observational study in Healthy, sponsored by Universidad de Murcia. Completed at 1 site in Spain. Open to female participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2017-03-27.
Sponsored by Universidad de Murcia · Observational
The purpose of this investigation is to assess the role of the genetic and environmental factor on circadian system, in free living conditions by the use of a female twin population. With the results from this study, the investigators expect to advance in the understanding of the role of the endogenicity of the circadian system variables such as temperature, activity, sleep and timing of food intake as the main cause of the coincidence of the rhythms. However, the investigators expected that some parameters are still dependent on environment to a relevant extent and, hence, amenable to change through external interventions.
Twin studies are a classic in the analysis of the relative contribution of genetic and environmental factors to behavior and other phenotypes. These models are most often used to separate genetic from environmental causes in the family resemblance methodology. These models based on twins have been previously carried out in chronobiology. In fact, during the years 1993 and 1994, Paul Linkowski et al., performed two relevant studies on the circadian system to analyze the relative contributions of hereditary and/or environmental factors of cortisol secretion and blood pressure, respectively, and concluded that genetic factors control some of the characteristics of cortisol and diastolic blood pressure circadian rhythmicity. The heritability of other circadian markers has also demonstrated such as morningness- eveningness (44%), sleep-related variables have also pointed to a relevant role of genetics with heritability estimates of sleep duration between 17% and 55%. However, to the investigators knowledge, the heritability of other relevant chronobiological markers, measured in free living conditions such as body temperature, actigraphy and sleep has not been studied.
These goals will be achieved through a specific approach:
Universidad de Murcia is the lead sponsor of 77 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All participants are voluntarily in the Murcia Twin Register in Spain. All participants are from the Spanish city of Murcia, located on the Southeast coast of the Mediterranean Sea.
IInclusion Criteria:
Exclusion Criteria:
Participation was completely voluntary and not remunerated. The subjects were organized into groups of 5 pairs, and were given an appointment at a university facility located in the city center, where informed consent was signed prior to the procedures indicated below. An informational letter was sent to pre-selected individuals. Later a phone call confirmed their availability. * Temperature rhythm was assessed continuously for 7 days using a temperature sensor and programmed to collect information every 10 min. * Body position and rest-activity rhythm were assessed over the same 7 days using a Acceleration Data Logger that record data every min and placed on the non-dominant arm by means of an elastic band, with its X axis parallel to the humerus bone. * Diet and sleep record were completed over the same week, their sleep schedules and their nutritional status.
Temperature record
Measured using temperature sensor
Time frame: Total of 1 week between Visit 1 and 2
Actigraphy record
Measured using Pendant Acceleration Data Logger
Time frame: Total of 1 week between Visit 1 and 2
Light record
Measured using Pendant Acceleration Data Logger
Time frame: Total of 1 week between Visit 1 and 2
Sleep record
Measured using Pendant Acceleration Data Logger
Time frame: Total of 1 week between Visit 1 and 2
Sleep Duration
Sleep duration will be computed from self-reported
Time frame: Total of 1 week between Visit 1 and 2
Total Energy Intake
Total energy intake in kcal/day will be computed from 7-day 24-hr dietary recalls
Time frame: Total of 1 week between Visit 1 and 2
Dietary Composition
Macronutrient and micronutrient intake will be computed from 7-days of self-reported 24-hr dietary recalls
Time frame: Total of 1 week between Visit 1 and 2
Dietary Intake Timing
Food timing will be self-reported and averaged across 7-days of 24-hr dietary recalls
Time frame: Total of 1 week between Visit 1 and 2
Chronotype
Assessed using the Morningness-Eveningness Questionnaire
Time frame: Total of 1 week between Visit 1 and 2
Plan to share: No
This study is completed, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Universidad de Murcia