An observational study in Neuropathy;Peripheral, sponsored by Swiss Paraplegic Research, Nottwil. Terminated at 1 site in Switzerland. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by Swiss Paraplegic Research, Nottwil · Observational
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
Sinus-like electrical stimulation may depolarize unmyelinated skin nociceptors involving NaV1.7 channels. In this case electrical stimulation may provoke pain already with very low currency intensity which normally not provoke pain in healthy subjects. This may be predictive for pain relief due to the sodium channel blocker lidocaine 5% patch.
The study will characterize pain states in peripheral neuropathic pain as well as within the painful scar in chronic postoperative pain with regard to the involvement of NaV1.7 channels.
In addition, the pain site in chronic postoperative pain (scar) will be characterized by laser-evoked potentials (LEP) and quantitative sensory testing (QST).
Pain related questionnaires will be obtained.
73 studies on the registry are indexed under Neuritis; 20 are open to participants now.
This study's enrollment of 65 is below the median of 123 across 20 observational studies indexed under Neuritis.
Browse Neuritis studies →Swiss Paraplegic Research, Nottwil is the lead sponsor of 71 studies on the registry; 8 are open to participants now.
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patients with neuropathic pain or with chronic postoperative pain
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria (both Groups):
individuals suffering from chronic pain
Diagnostic Test: neurophysiology
individuals suffering from neuropathic pain
Diagnostic Test: neurophysiology
electrophysiologic measurements of peripheral nerves
change in pain intensity
numeric rating scale (NRS), rating from 0-10, 0=no pain, 10=maximum pain imaginable
Time frame: at baseline and during electric nerve stimulation
heat pain threshold
Ramped stimuli (+1 degree Celsius / sec) that are terminated when the subject presses a button.
Time frame: baseline
cold pain threshold
Ramped stimuli (-1 degree Celsius / sec) that are terminated when the subject presses a button.
Time frame: baseline
mechanical detection threshold
Fine plastic hairs with different bending forces are applied to the skin to determine the mechanical detection threshold.
Time frame: baseline
mechanical pain threshold
Differently weighted pinprick stimuli are applied at a rate of 2sec on and 2sec off in an ascending order until the first percept of sharpness is reached.
Time frame: baseline
mechanical pain sensitivity
Differently weighted pinprick stimuli are applied to obtain a stimulus- response function for pinprick-evoked pain. Subjects were asked to give a pain rating for each stimulus (rating from 0-10, 0=no pain, 10=maximum pain)
Time frame: baseline
dynamic mechanical allodynia
Different stimuli, tactile and pinprick are applied with the subject giving numerical pain ratings for each stimulus (rating from 0-10, 0=no pain, maximum pain).
Time frame: baseline
vibration detection threshold
Tuning fork is placed over a bony prominence until the subject cannot not feel vibration any more.
Time frame: baseline
pressure pain threshold
A pressure gauge that exerts forces of ascending stimulus intensities is applied as a slowly increasing ramp over a muscle.
Time frame: baseline
LEP latency
latency of N2 and P2 components of laser evoked potential signal curve
Time frame: baseline
LEP amplitude
amplitude of laser evoked potential signal curve
Time frame: baseline
stadium of pain chronification
assessment of the stadium of pain chronification (stadium 1-3) using standardized questionnaire
Time frame: baseline
pain severity
assessment of pain severity (grade 1-4) using the Chronic Pain Grading Questionnaire
Time frame: baseline
physical health status
assessing the physical health status using the Short Form-12 questionnaire
Time frame: baseline
mental health status
assessing the mental health status using the Short Form-12 questionnaire
Time frame: baseline
anxiety
assessing anxiety using the Hospital Anxiety and Depression Scale questionnaire
Time frame: baseline
depression
assessing Depression using the Hospital Anxiety and Depression Scale questionnaire
Time frame: baseline
Plan to share: No
This study is terminated, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Swiss Paraplegic Research, Nottwil