An interventional study of Eccentric (KREHA) training and Standard clinical routine strength (STAN) training in Spinal Cord Injury, sponsored by Swiss Paraplegic Research, Nottwil. Not yet recruiting at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-28.
Sponsored by Swiss Paraplegic Research, Nottwil · Not applicable, Interventional, and Supportive care
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Among 47 studies in Spinal Cord Injuries by Swiss Paraplegic Research, Nottwil — 8 open to participants now, 8 under way, none of them phase 3. Spinal Cord Injuries · Swiss Paraplegic Research, Nottwil.
Among the 47 studies in Spinal Cord Injuries by Swiss Paraplegic Research, Nottwil, this one is the 12th largest by planned enrollment of the 24 interventional ones that give a count, is one of 4 that started in 2026, is one of 20 with no phase, and was the 41st registered.
2,026 studies on the registry are indexed under Spinal Cord Injuries; 538 are open to participants now.
Browse Spinal Cord Injuries studies →8 of the 47 studies in Spinal Cord Injuries by Swiss Paraplegic Research, Nottwil are open now, in 3 countries. Recruiting first, the newest first:
Swiss Paraplegic Research, Nottwil · Sites in Switzerland
Ages 18–70
Swiss Paraplegic Research, Nottwil · Sites in Switzerland
Ages 18+
Swiss Paraplegic Research, Nottwil · Sites in Switzerland
Ages 18–75
Swiss Paraplegic Research, Nottwil · Sites in Switzerland
Ages 18+
Swiss Paraplegic Research, Nottwil · Sites in Switzerland
Ages 18+ · Women only
By country, each count listing its studies:
Of the 375 Spinal Cord Injuries studies recruiting now, 166 (44%) set no upper age limit and 158 (42%) stop at 75 or younger; 41 take children under 18; 52 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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47 studies; the count open now beside each. This study's row is marked.
First in 2009; this study’s year is marked. 4 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 20 is below the median of 24 across 1,634 interventional studies indexed under Spinal Cord Injuries.
Median enrollment 20 across the 24 interventional studies, 50 across the 23 observational. Of the 37 that completed or were terminated, 1 (3%) have results posted.
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Swiss Paraplegic Research, Nottwil is the lead sponsor of 71 studies on the registry; 8 are open to participants now.
2 of the studies in Spinal Cord Injuries by Swiss Paraplegic Research, Nottwil that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06870331Swiss Paraplegic Research, NottwilThe Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury | 2027-06 |
| NCT07165353Swiss Paraplegic Research, NottwilVirtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI | 2027-11-30 |
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Among the 47 studies in Spinal Cord Injuries by Swiss Paraplegic Research, Nottwil, from their registry updates:
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The goal of this clinical trial is to assess the effects of eccentric arm-crank (KREHA) training compared to standard clinical routine strength (STAN) training in individuals undergoing primary spinal cord injury (SCI) rehabilitation.
The main questions this trail aims to answer are:
Participants will:
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The eccentric training intervention consists of 20 training sessions performed on a symmetric arm-crank (Krafttraining mittels exzentrischer Handkurbel, KREHA) device. The training sessions have a duration of approximately 30 min and will be completed within twelve weeks, with a maximum of three sessions per week.
Procedure: Eccentric (KREHA) training
The standard strength training intervention consists of a total of 20 training sessions at the gym of the study center, performed following clinical routine procedures. The training sessions have a duration of approximately 60 min and will be completed within twelve weeks, with around three sessions per week.
Procedure: Standard clinical routine strength (STAN) training
20 eccentric resistance training sessions will be performed on a symmetric arm-crank ergometer in a supine position.
The regular strength training intervention consists of a total of 20 training sessions at the gym of the study center, performed following clinical routine procedures.
Upper body strength
Change in upper body strength will be measured by a one-repetition maximum (1RM) bench press (in kg). The maximum amount of weight that can be pushed upwards for one repetition, while lying in a supine position on a weight training bench.
Time frame: < 1 week pre and 12 weeks post intervention start.
Upper body strength
Change in upper body strength measured by a 1RM bench pull (in kg). The maximum amount of weight that can be pulled upwards for one repetition, while lying in a prone position on a weight training bench.
Time frame: < 1 week pre and 12 weeks post intervention start.
Handgrip strength
Change in maximum strength of three handgrip measurements (in kg) of both hands using a Jamar Handgrip Dynamometer.
Time frame: < 1 week pre and 12 weeks post intervention start.
Aerobic performance
Change in cardiopulmonary adaptations, measured by aerobic performance in an exercise test on a regular arm-crank ergometer. A ramp protocol starting at 20 Watt followed by 1 Watt / 6 sec increments to failure will be used. The following parameters will be evaluated during this aerobic endurance test: power at failure at the end of the test (in Watt), peak oxygen uptake during the test (in ml/kg/min), maximal heart rate (bpm)
Time frame: < 1 week pre and 12 weeks post intervention start.
Muscle volume
Magnetic resonance imaging (MRI) of relevant upper body muscles of the dominant upper arm and shoulder will be used to measure change in muscle volume.
Time frame: < 1 week pre and 12 weeks post intervention start.
Arm circumference
Change in arm circumference of the right and left lower and upper arm (in cm), will be used to estimate muscle volume.
Time frame: < 1 week pre and 12 weeks post intervention start.
Functioning during activities of daily living
Change in functioning during activities of daily living will be assessed by the Spinal Cord Independence Measure (SCIM) as extracted from clinical records. The SCIM total score ranges from 0-100, with higher scores indicating higher levels of functional independence.
Time frame: < 1 week pre and 12 weeks post intervention start.
Health-related quality of life
Change in health-related quality of life will be assessed using the Short Form Health Survey (SF-12). Weighted physical and mental component scores range from 0-100, with higher scores indicating better physical or mental health.
Time frame: < 1 week pre and 12 weeks post intervention start.
Feasibility of the KREHA training (total number of training sessions)
Successful implementation of the KREHA training in the clinical routine, by assessing whether the 20 KREHA sessions are completed within 12 weeks.
Time frame: Throughout the intervention phase, week 0-12
Feasibility of the KREHA training progression (number of sessions adapted)
Feasibility of the KREHA training progression, by assessing how many training sessions needed to be adapted.
Time frame: Throughout the intervention phase, week 0-12
Feasibility of the KREHA training progression (power adaptation)
Feasibility of the KREHA training progression, by assessing how much the target power (in Watts) of a training session needed to be adapted compared to the initially planned progression.
Time frame: Throughout the intervention phase, week 0-12
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Dec 2026; primary completion for Dec 2028, 24 months later.
Of 790 non-industry interventional studies with no phase under Spinal Cord Injuries, half reached primary completion within 37 months of starting (the median), counting those still running; a quarter within 18 and three quarters within 65. This study's planned 24 months is below that.
Counting every sponsor, half of 839 studies reached it within 36 months; a quarter within 17 and three quarters within 64.
Since we started tracking on Sep 25, 2026, the dates moved once, on Sep 28, 2026: start Jul 2026 → Dec 2026, primary completion Jul 2028 → Dec 2028 and completion Jul 2028 → Dec 2028.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Swiss Paraplegic Research, Nottwil