ClinicalTrials.gg
RecruitingNCT06121232Updated Oct 2, 2026

Exploring the Benefit of Neuromodulation in Treating Chemo-induced Peripheral Neuropathy Using Peripheral Neuropathy Markers (Meissner's Corpuscles and Epidermal Nerve Fiber Density) and Sensory Testing (Quantitative Sensory and Gait Testing): A Single Center Feasibility Study

An interventional study of Abbott® DRG / Abbott®/Medtronic® SCS and Control Group in Neuropathy;Peripheral, sponsored by M.D. Anderson Cancer Center. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-02.

Sponsored by M.D. Anderson Cancer Center · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Nov 2023; still recruiting 3 years later.
Updated Oct 2, 2026Now RecruitingSite recruiting status changed+3 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

To learn if a process called neuromodulation can help to improve pain due to CIP

Read the detailed description

Inclusion Criteria:

  • Ability to understand and the willingness to sign a written informed consent document
  • Patients diagnosed with CIPN lower extremity due to either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds
  • Patients seen at Pain Management Center at MD Anderson Cancer Center
  • Patient ages greater or equal to 18 years but less than or equal to 85 years

Exclusion Criteria:

  • Patients with cognitive dysfunction
  • Patient with recent history (\<6 months) of drug or alcohol abuse
  • Patients with open skin lesion or undergoing antibiotic therapy for local for systemic infection
  • Patients with painful diabetic peripheral neuropathy or preexisting peripheral neuropathy
02

Conditions studied

  • Neuropathy;Peripheral

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03

In context

Neuritis

73 studies on the registry are indexed under Neuritis; 20 are open to participants now.

This study's planned enrollment of 24 is below the median of 48 across 51 interventional studies indexed under Neuritis.

Browse Neuritis studies →

Lead sponsor

M.D. Anderson Cancer Center is the lead sponsor of 3,047 studies on the registry; 578 are open to participants now.

Of its 612 completed or terminated interventional studies of FDA-regulated products, 409 (67%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Ability to understand and the willingness to sign a written document
  • Patients diagnosed with CIPN lower extremity due to either vinca alkaloids, taxanes, bortezomib, thalidomide, platinum-based compounds
  • Patients seen at Pain Management Center at MD Anderson Cancer Center
  • Patient ages greater or equal to 18 years but less than or equal to 85 years

Exclusion criteria

Exclusion Criteria

  • Patients with cognitive dysfunction
  • Patient with recent history (\<6 months) of drug or alcohol abuse
  • Patients with open skin lesion or undergoing antibiotic therapy for local for systemic infection
  • Patients with painful diabetic peripheral neuropathy or preexisting peripheral neuropathy
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
24 participants (estimated)

Study arms

  • Experimental
    Treatment Group

    Group 1 will receive neuromodulation.

    Device: Abbott® DRG / Abbott®/Medtronic® SCS

  • Experimental
    Control Group

    Group 2 will not receive neuromodulation.

    Other: Control Group

Interventions

  • DeviceAbbott® DRG / Abbott®/Medtronic® SCS

    Participants will receive 1 of 2 neuromodulation procedures based on if participants are expected to have an MRI in the near future.

  • OtherControl Group

    Participants will not receive any intervention

06

What researchers measure

Primary outcomes

  1. Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0

    Time frame: through study completion; an average of 1 year.

07

Study locations

1 of 1 sites recruiting
08

References and documents

09

Updates

1 registry update since Sep 25, 2026
Status
Active, not recruiting→Recruiting
changed Oct 2, 2026
Sites
M D Anderson Cancer Center is now Recruiting
Oct 2, 2026
Primary completion
Jun 1, 2026→Jun 1, 2028
Oct 2, 2026
Study completion
Jun 1, 2026→Jun 1, 2028
Oct 2, 2026
Contact
Study contact now listed: added s•••@mdanderson.org · •••9530. See the current contact
Oct 2, 2026
Site contacts
Changed at 1 site. See the sites
Show the site
  • M D Anderson Cancer Center · Houston, United StatesContact added s•••@mdanderson.org · •••9530Contact added (no phone or email listed)
Oct 2, 2026
Show all 1 update
  1. Oct 2, 2026
    Active, not recruiting→Recruiting
    M D Anderson Cancer Center is now Recruiting
    Primary completion Jun 1, 2026→Jun 1, 2028
    Study completion Jun 1, 2026→Jun 1, 2028
    Contact Study contact now listed: added s•••@mdanderson.org · •••9530. See the current contact
    Site contacts Changed at 1 site. See the sites
    Show the site
    • M D Anderson Cancer Center · Houston, United StatesContact added s•••@mdanderson.org · •••9530Contact added (no phone or email listed)
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT06121232
Collaborators
Foundation for Anesthesia Education and Research
Responsible party
Sponsor
First posted
Nov 7, 2023
Start date
Nov 2, 2023
Primary completion
Jun 1, 2028 (estimated)
Completion
Jun 1, 2028 (estimated)
Last update
Oct 2, 2026

Study contacts

Saba Javed, M D
Contact
sjaved@mdanderson.org
(713) 792-9530
Saba Javed, M D
principal investigator · M.D. Anderson Cancer Center

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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