An observational study in Pesticide Poisoning, sponsored by Centre Leon Berard. Completed. Open to male participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-02-09.
Sponsored by Centre Leon Berard · Observational
An association has been suggested with several diseases including cancer and IARC has classified several pesticides as carcinogenic, probably carcinogenic. There is a need for a better characterisation of environmental pesticides exposures and identification of suitable biomarkers of exposure and effect. A better understanding of the impact of pesticide exposure on metabolomic, transcriptomic and epigenetic changes, is essential to strengthen epidemiological hypotheses on the association with several cancer types.
The main objective of the project is to validate a GIS (geographic information system) based method to assess environmental pesticide exposures, using environmental (contamination of housedust) and biological (blood and urine samples) measures. The project aims further to investigate a potential link between housedust contamination and biological measures in healthy non-smoking male residents and explore the impact of environmental pesticide exposure on metabolomics, transcriptomic and epigenetic parameters.
The project involves a pilot phase involving repeated (twice) sampling in 20 male non-smoking volunteers living in the Beaujolais region (France) to perform appropriate calibrations for metabolomic, transcriptomic and epigenetic analyses. The main study will be conducted in a sample of 150 male non-smoking volunteers and 50 professional pesticides applicators from the same region (3 sampling periods).
209 studies on the registry are indexed under Poisoning; 26 are open to participants now.
This study's enrollment of 166 is above the median of 121 across 94 observational studies indexed under Poisoning.
Browse Poisoning studies →Centre Leon Berard is the lead sponsor of 206 studies on the registry; 61 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Healthy volunteers living in the Beaujolais region (France)
Exclusion Criteria:
A specific questionnaire with professional information about pesticide uses is added for this arm Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling
Biological: Questionnaire, blood, urine, hair and dust samplings
Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling
Biological: Questionnaire, blood, urine, hair and dust samplings
level of pesticide exposures
environmental, occupational and domestic exposures
Time frame: up to 2 years
No study locations are listed for this record.
This study is completed, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.
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Centre Leon Berard