An interventional study of 400 mg of Magnesium Oxide twice daily for 24 weeks and Open label (none) in Obesity, sponsored by Providence VA Medical Center. Completed at 1 site in United States. Open to participants aged 30 Years and older. Per ClinicalTrials.gov, last updated 2023-02-24.
Sponsored by Providence VA Medical Center · Not applicable, Interventional, and Prevention
The objective of this study is to investigate whether nutritional supplementation with magnesium can improve cardiovascular structure and function in participants with obesity - with a long-term goal of preventing clinical heart failure. Specifically, in a randomized open-label pilot study, we will assess whether dietary Magnesium (Mg) supplementation (versus no supplementation) for 24 weeks in obese patients will improve left ventricular (LV) mass.
The investigators propose a 24-week therapeutic trial involving 40 participants with obesity from the Providence VA Medical Center without clinical heart failure. 20 participants will be treated with 400 mg of Magnesium Oxide twice daily, while 20 participants will receive no treatment. The trial tests the hypothesis that oral Mg supplementation will improve: LV structure (by LV mass, steatosis, and ECV), LV function (systolic and diastolic), vascular health (systolic blood pressure and aortic pulse wave velocity) and visceral adiposity.
Body mass index greater than 30 kg/m2
Exclusion Criteria:
20 participants will be treated with 400 mg of Magnesium Oxide twice daily
Dietary Supplement: 400 mg of Magnesium Oxide twice daily for 24 weeks
20 participants will receive no treatment
Other: Open label (none)
Left ventricular mass (by cardiac MRI)
Time frame: 24 weeks
Left ventricular myocardial triglyceride content (by cardiac MRI)
Time frame: 24 weeks
Left ventricular extracellular volume fraction (by cardiac MRI)
Time frame: 24 weeks
Systolic blood pressure
Time frame: 24 weeks
Aortic pulse wave velocity (by cardiac MRI)
Time frame: 24 weeks
This study is completed, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.
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Providence VA Medical Center